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GI
PANCE review
152
Health Care
Graduate
08/08/2011

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Term
ulcer pain relieved by eating food
Definition
duodenal
Term
MCC of PUD
Definition
H Pylori followed by NSAIDs
Term
tx of H Pylori
Definition
triple therapy
PPI + clarithro + amox
metro + bismuth + tetracycline
Term
tx of NSAID ulcers
Definition
PPI qd
D/C NSAID, if not possible take misoprostol
Term
MCC UGI bleed
Definition
PUD
Term
free air under the diaphragm
Definition
perforation
Term
strongest risk factor for gastric adenocarcinoma
Definition
chronic H Pylori infection
Term
signs of gastric adenocarcinoma mets
Definition
Virchow's node
Sister Mary Joseph Node
Blumer's shelf
Krukenberg Tumor
Term
____________ helps maintain continence by minimizing trauma during BMs
Definition
hemorrhoids
Term
internal vs external hemorrhoids
Definition
internal = above dentate line
external = below dentate line
Term
tx of internal hemorrhoids
Definition
high fiber diet, fluids, stool softener
Term
what is the timeline for clot evacuation in external hemorrhoids?
Definition
must be done within 48 hours of sx onset
Term
communcation between an abscess and an opening in the anal canal
Definition
anal abscess
Term
anal abscesses normally drain through where?
Definition
internal sphincters
Term
a split in anal mucosa, usually occurs midline just distal to the dentate line
Definition
anal fissure
Term
mature anal ulcers are associated with a skin tag called a
Definition
sentinel pile
Term
tearing burning pain that subsides over hours and is associated with constipation
Definition
anal fissure
Term
abscess in the sacrococcygeal cleft with resultant sinus tract development
Definition
pilonidol cyst
Term
painful fluctuant area at sacrum - small midline pits or absecesses near midline of sacrum and coccyx, chronic draining sinuses with hair protruding from pits
Definition
pilonidol cysts
Term
gold standard for dx of mesenteric ischemia
Definition
laparotomy
Term
pain out of proportion to PE findings, N/V/D, blood stools
Definition
mesenteric ischemia
Term
MC GI complication from CV surgery
Definition
ischemic colitis
Term
RUQ pain, jaundice, fever with chills
Definition
Charcot's triad - associated with cholangitis
Term
RUQ abd pain, jaundice, fever w/ chills, hypotension, mental confusion
Definition
Reynold's Pentad - acute supperative colangitis
Term
bacterial infection superimposed over obstructed biliary tree from gallstone, stricture, or neoplasm
Definition
colangitis
Term
Tx of colangitis
Definition
PTC - percutaneous transhepatic cholangiogram
ERCP - endoscopic retrograde cholangiopancreatography
MRC - magnetic resonance cholangiography
Term
can be used to dx and tx colangitis
Definition
ERCP
Term
gallbladder wall inflammation
Definition
cholecystitis
Term
causes of cholecystitis
Definition
cholelithiasis, bile statis, bacterial infection
Term
acalculous cholecystitis = no stone present, associated with (5)
Definition
major surgery
critical illness
burns
trauma
TPN
Term
how to dx cholecystitis
Definition
abdominal U/S, HIDA scan
Term
appendicitis leads to gangrene and perforation if not treated in how long?
Definition
36 hours
Term
+ psoas and obturator signs
Definition
appendicitis
Term
best test to dx appendicitis
Definition
helical CT
Term
patchy, transmural inflammation (skip lesions) involving any segment of the GI tract from mouth to anus
Definition
Crohn's disease
Term
where does Crohn's commonly and not commonly affect?
Definition
commonly = proximal colon (ileocecal)
uncommon = Terminal Ileum
Term
initial lesions of Crohn's disease
Definition
apthoid ulcers and focal crypt abscesses
Term
IBD where UGI tract and rectum are often spared
Definition
Crohn's disease
Term
Crohn's is associated with caseating or non-caseating granulomas?
Definition
non-caseating
Term
extraintestinal manifestations of Crohn's disease
Definition
increased risk of gallstones, acute arthropathy, uveitis, nephrolithiasis, E. nodosum, pyoderma gangrenosum, vertebral fx
Term
T or F
Crohn's is often ASCA positive?
Definition
True
Term
most episodes of pancreatitis are associated with?
Definition
alcoholism
Term
pancreatitis is diagnosed/staged based on?
Definition
Ranson's critera
Term
Cullen's sign, Grey Turner's Sign
Definition
pancreatitis
cullen = bruising around umbilicus
grey turner = bruising at flanks
Term
tx of pacreatitis
Definition
pain control
replace pancreatic enzymes
H2 blockers, or PPI
octreotide
low fat diet
oral hypoglycemic agent or insulin
cyanocobalamin
Term
acute LLQ abdominal pain, leukocytosis, loose bowel movement, N/V
Definition
diverticulitis
Term
CT = stranding, fatty infiltration, streaking, dirty fat, phlegon
Definition
diverticulitis
Term
tx of diverticulitis
Definition
cipro + flagyl
augmentin
low residue diet
surgical resection of infected area
Term
diagnostic criteria for IBS
Definition
Rome II criteria
Term
IBS is often relieved by
Definition
Term
IBS is often relieved by
Definition
defecation
Term
IBS > 50 yo, what test?
Definition
colonoscopy
Term
tx of IBS
Definition
diarrhea = trial of lactose free diet, loperamide
constipation = high fiber, laxatives
Term
3 phases of acute hepatitis
Definition
prodromal
icteric
convalescent
Term
how is Hep A transmitted?
Definition
fecal-oral
Term
how is Hep B transmitted?
Definition
parenteral, sexual contact
blood
saliva
semen
vaginal secretion
mother - baby
Term
HBsAg
Definition
acute HBV infection
Term
anti-HBs
Definition
immunized or recovered acute infection
Term
HBeAg
Definition
viral replication and infectivity
Term
Hep D must be seen in conjunction with what?
Definition
Hep B
Term
how is Hep E transmitted? who is it often lethal in?
Definition
transmitted enterically through water-borne epidemics.
often fatal to pregnant women
Term
chronic active hepatitis... 4 types
Definition
majority of HCV and minority of HBC pts
autoimmune hepatitis
induced by agents such as minocycline, nitrofurantoin, NSAIDs, herbals, OTC's
metabolic liver disease - Wilson's, hemochromatosis
Term
difference between autoimmune hepatitis type 1 and type 2
Definition
1 = ANA, ASMA - affects nuclei and/or smooth muscle
2 = anti LKM1 - affects liver/kidney microsomes
Term
tx of autoimmune hepatitis
Definition
prednisone, corticosteroids, immunosupprsesives
Term
prognosis of alcoholic hepatitis
Definition
grave if continues to drink - 5 year survival = 40%
Term
intra-abdominal abscess is associated with (4)
Definition
pancreatitis
acute cholecysitis
crohn's
appendicitis
Term
positive murphy's sign
Definition
cholecystitis
Term
difficulty swallowing
Definition
dysphagia
Term
painful swallowing
Definition
odynophagia
Term
sensation of a lump in the throat without physical mass
Definition
globus pharyngeus
Term
this muscle prevents reflux after swallowing
Definition
cricopharyngeal
Term
GERD can lead to what?
Definition
Barrett's esophagitis which predisposes the person to malignancy
Term
tx of GERD
Definition
lifestyle mods
H2RA
PPI
Term
disorders of esophageal motility (6)
Definition
neurogenic dysphagia
Zenker's diverticulum
esophageal stenosis
achalasia
diffuse esophageal spasm
scleroderma
Term
outpouching of the posterior hypopharynx that can cause regurgitation of undigested food and liquid into the pharynx several hours after eating
Definition
Zenker's diverticulum
Term
difficulty with both liquids and solids caused by injury or disease of the brainstem or the branial nerves involved in swallowing
Definition
neurogenic dysphagia
Term
slow progression of solid food dysphagia indicates ___________ and rapid progression indcates ___________.
Definition
slow = benign
rapid = malignant
Term
global esophageal disorder in which peristalsis is decreased and lower esophageal sphincter tone is increased causing a slowly progressive dysphagia with episodic regurgitation and chest pain
Definition
achalasia
Term
study that can reveal both structural and motor abnormalities
Definition
barium swallow
Term
parrot-beaked appearance on barium swallow
Definition
achalasia
Term
test used to asses the strength and coordination of peristalsis
Definition
esophageal monometry
Term
MC types of esophageal neoplasms (2)
Definition
SCC and adenocarcinoma
Term
Barrett's esophagitis is associated with what type of cancer?
Definition
adenocarcinoma
Term
esophageal cancers are frequently related to what 2 things?
Definition
cigarette smoking and drinking
Term
best initial test to visualize esophageal neoplasms
Definition
biphasic barium esophagram
Term
linear mucosal tear in the esophagus, generally at the gastroesophageal junction, that occurs with foreful vomiting or retching causing hematemesis
Definition
Mallory-Weiss tear
Term
underlyng cause of esophageal varices
Definition
portal HTN due to cirrhosis
Term
Budd Chiari syndrome may cause thrombosis of the portal vein leading to
Definition
esophageal varices
Term
tx of esophageal varices
Definition
hemodynamic support - high volume fluid replacement
vasopressors
immediate control of bleeding - endoscopic therapy and pharmacologic vasoconstriction (octreotide) are preferred.
Term
burning, gnawing pain that often radiates to the back
Definition
PUD
Term
ulcer pain that worsens with food --> anorexia and weight loss
Definition
gastric ulcer
Term
gastrin secreting tumor (gastrinoma)
Definition
Seollinger-Ellison syndrome
Term
apparent PUD that is refractory to tx, think what?
Definition
Zollinger-Ellison syndrome
Term
2 tests used to diagnose ZES
Definition
fasting gastrin > 150 pg/mL
scretin test --> increases in gastrin levels > 200 pg/mL
Term
dyspepsia and weight loss associated with anemia and occult GI bleeding in a pt older than 40
Definition
gastric adenocarcinoma
Term
most common extra-nodal site for non-Hodgkin's lymphoma
Definition
stomach
Term
antibiotic associated diarrhea is almost always caused by
Definition
clostridium difficile which in the most severe cases causes pseudomembranous colitis
Term
most small bowel obstructions are due to (2)
Definition
adhesions or hernias
Term
large bowel obstruction is likely due to
Definition
neoplasm
Term
high pitched bowel sounds that come in rushes, associated with air-fluid levels
Definition
small bowel obstruction
Term
twisting of any portion of the bowel on itself, most commonly the sigmoid or cecal area
Definition
volvulus
Term
inflammation of the small bowel with the ingestion of gluten containing food such as wheat, rye, and barley leading to malabsorption
Definition
celiac disease
Term
diarrhea, steatorrhea, weight loss, weakness, abdominal distention, failure to thrive, IgA antiendomysial and antitissue transglutaminase antibodies are the serologic screen
Definition
celiac disease
Term
what is needed to confirm the dx of celiac sprue?
Definition
small bowel biopsy
Term
nutritional deficiencies often associated with celiac sprue (5)
Definition
iron,
B12
folic acid
calcium
vitamin D
Term
bloody diarrhea is more often associated with crohn's or ulcerative colitis?
Definition
UC
Term
MCC of chronic or recurrent abdominal pain in the US
Definition
IBS
Term
invagination of a proximal segment of the bowel into the portion just distal to it "telescoping"
Definition
intussusception
Term
severe colicky pain associated with currant jelly stool and a sausage like abdominal mass
Definition
intussusception
Term
what test may be both diagnostic and therapeutic in children with intussusception?
Definition
air or barium enema
Term
large outpouchings of the mucosa in the colon.
Definition
diverticulosis
Term
inflammation of diverticula caused by obstructing matter
Definition
diverticulitis
Term
tx of diverticulosis
tx of diverticulitis
Definition
diverticulosis = high fiber diet
diverticulitis = low residue diet
Term
optimal test to evaluate for ischemia of the colon
Definition
colonoscopy
Term
congenital aganglionosis of the colon leading to functional obstruction in the newborn
Definition
Hirschsprung's disease
Term
extreme dilation and immobility of the colon, representing a true emergency
Definition
toxic megacolon
Term
family members of those with familial polyposis syndrome should be evaluated how often starting when?
Definition
every 1-2 years starting at 10-12 years of age
Term
criteria used to stage colorectal cancer
Definition
Dukes criteria
Term
tx of anorectal abscess/fistula
Definition
surgical drainage and WASH regimen
warm water cleansing,analgesics, stool softeners, high fiber diet
Term
stage 1-4 hemorrhoids
Definition
1 = confined to anal canal and may bleed with defecation
2 = protrude from anal opening but reduce spontaneously
3 = require manual reduction after BM
4 = chroncially protruding and risk strangulation
Term
MC of appendicitis
Definition
fecalith
Term
pain of appendicitis starts where? why? eventually localizes where?
Definition
starts - umbilicus due to embryologic connections
localizes to RLQ (McBurney's point)
Term
pt is supine and attempts to raise the leg against resistance
Definition
psoas sign
Term
pt is supine and attempts to flex and internaly
Definition
Term
pt is supine and attempts to flex and internally rotate the right hip with knee bent
Definition
obturator sign
Term
is lipase or amylase more sensitive for pancreatitis?
Definition
lipase
Term
what is courvoisier's sign
? what is it associated with?
Definition
jaundice accompanied by a palpable gallbladder
pancreatic neoplasm
Term
classic triad of pancreatic calcification, steatorrhea, and DM occurs in what % of pacreatitis pts?
Definition
20%
Term
surgical tx used for pancreatic cancer without mets?
Definition
modified Whipple
Term
choledocholithiasis
Definition
gallstones
Term
obstruction of the bile duct, generally by a stone, leading to chronic inflammation
Definition
acute cholecystitis
Term
colicky epigastric of RUQ pain that ofen occurs after a fatty meal
Definition
cholecystitis
Term
primary sclerosing cholangitis is associated with?
Definition
cholangiocarcinoma and increased pancreatic and colorectal cancer
Term
deficiency leading to night blindness and dry skin
Definition
vitamin A
Term
deficiency leading to Rickets and osteomalacia
Definition
Vitamin D
Term
deficiency leading to hemolytic anemia and degenerative nerve changes
Definition
Vitamin E
Term
deficiency leading to excess bleeding
Definition
vitamin K
Term
deficiency leading to beriberi (nervous tingling, poor coordination, edema, weakness, cardiac dysfunction)
Definition
thiamin (B1)
Term
deficiency leading to oral inflammation and eye disorders
Definition
Riboflavin
Term
deficiency leading to flushing
Definition
niacin
Term
deficiency leading to tingling, fatigue, and headache
Definition
pantothenic acid
Term
deficiency leading to dermatitis, tongue pain, anemia, depression
Definition
biotin
Term
deficiency leading to headache, anemia, seizures, flaky skin, sore tongue
Definition
B6
Term
deficiency leading to megaloblastic anemia, sore tongue, diarrhea, mental disorders
Definition
folate
Term
deficiency leading to megaloblastic anemia, poor nerve function
Definition
B12
Term
deficiency leading to scurvy (poor wound healing, petechiae, bleeding gums)
Definition
vitamin C
Term
esophageal atresia is commonly associated with
Definition
tracheoesophageal fistulas
Term
projectile vomiting, olive shaped mass, "string sign"
Definition
pyloric stenosis
Term
MC location of bowel atresia
Definition
ileum
Term
congenital absence of Meissner's and Auerbach's plexuses
Definition
Hirschsprung's disease
Term
rare autosomal recessive disorder associated with inability to metabolize the protein phenylalanine. associated with a mousy odor
Definition
phenylketonuria (PKU)
Term
tx of PKU
Definition
strict control of protein intake for life. If not caught and treated by age 3 will lead to irreversible brain damage.
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