Term
| What are the cardinal symptoms of GERD? |
|
Definition
| heartburn and regurgitation |
|
|
Term
| Major factors that contribute to GERD? |
|
Definition
1. Transient lower esophageal sphincter relaxation.
2. Hiatal hernia
3. Irritant effects of reluxate
4. abnormal esophageal clearance or peristalsis.
5. delayed gastric emptying. |
|
|
Term
| examples of medication that cause loss of LES tone? |
|
Definition
progesterone
diazepam
trycyclics
calcium channel blocker
anticholinergics
b adrenergic agonists -dobutamine, epi
a adrenergic antagonist-phentolamine |
|
|
Term
| lower esophageal sphincter (LES) –normal pressure is _______ |
|
Definition
|
|
Term
Los Angeles classification of esophagitis?
Mucosal break > 5mm |
|
Definition
|
|
Term
Los Angeles classification of esophagitis?
Mucosal break < 5 mm in length |
|
Definition
|
|
Term
Los Angeles classification of esophagitis?
Mucosal break continuous between > 2 mucosal folds |
|
Definition
|
|
Term
Los Angeles classification of esophagitis?
Mucosal break >75% of esophageal circumference |
|
Definition
|
|
Term
| What is the goal of pharm tx of GERD? |
|
Definition
| The aim of pharmacologic treatment is to maintain esophageal pH above 4 to promote healing and reduce symptoms |
|
|
Term
Significantly more effective than H2RAs for both symptom resolution and healing of erosive esophagitis
Also effective in more severe cases of GERD
Most patients respond well to standard therapy, but some require prolonged and/or high-dose treatment |
|
Definition
|
|
Term
| Surgical tx of GERD which entitles a partial fundal wrap around the esophagus |
|
Definition
|
|
Term
| surgical procedure for GERD which entitles a complete wrap of the gastric fundus around the esophagus |
|
Definition
Nissen fundoplication
Better than Gastropexy in the long run |
|
|
Term
| empiric tx for gerd, tx for __ weeks without the need for studies, confirms the diagnosis. |
|
Definition
|
|
Term
| A change in the esophageal epithelium of any length that can be recognized at endoscopy and is confirmed to have intestinal metaplasia by biopsy” |
|
Definition
|
|
Term
Definitive diagnosis of H-Pylori is made with
______? |
|
Definition
| biopsy of gastric mucosa. |
|
|
