Term
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Definition
Have cysteine residues (Cys) at active site and cleave after ASPartate residues in substrate proteins
Bring about events of apoptosis by cleaving different target proteins |
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Term
| DNAase, nuclear lamins, cytoskeletal proteins |
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Definition
| the key target proteins of caspsases inhibit? |
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Term
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Definition
| what is the key initiator caspase |
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Term
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Definition
| caspase 9 is activated by binding to ? in a multisubunit complex --> Apoptosome --> cleaves and activates effector caspases, like caspase-3 --> cell death |
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Term
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Definition
Approximately 20 proteins
3 functional groups; 1 antiapoptotic and 2 proapoptotic |
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Term
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Definition
| what are the two BH3 members that inhibit antiapoptotic proteins (Bcl-2, Bcl-xL) |
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Term
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Definition
| Due to the inhibition of BCL2 and BCL-XL, what two multi-domain proapoptotic proteins are activated and released |
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Term
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Definition
Inhibitors of apoptosis
Members directly interact with caspases and inhibit them |
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Term
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Definition
| Oligomer formation by Bax and Bak --> also releases these proteins which inhibit IAP and activate caspases |
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Term
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Definition
| these two events; DNA damage, polypeptides of TNF family are signals of? |
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Term
| apoptosis will be inhibited |
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Definition
| when there are polypeptide growth factors related to nerve growth factor (NGF) what will happen |
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Term
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Definition
| what phosphorylates p53 and transcriptionally activates the BH3 only genes? |
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Term
| 14-3-3 chaperone proteins |
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Definition
| Phosphorylation of Bad (a proapoptotic) creates binding site for ? |
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Term
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Definition
| what is sequestered by chaperone proteins in its inactive form |
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Term
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Definition
| Activation of ___ is responsible for killing of target cells such as cancer cells, virus infected cells, excess lymphocytes at the end of immune response |
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