Term
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Definition
prevention of nausea & vomiting
5HT-antagonists
headache, seizures, lightheadedness, constipation/diarrhea, transient LFT increases |
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Term
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Definition
emesis, dysmotility, gastroparesis
DA-antagonists
sedation, headache, EPRs, anxiety, depression, leukopenia, hypotension, diarrhea |
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Term
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Definition
management of opioid-induced bowel dysfunction (including post-op ileus, constipation)
peripheral MOP receptor antagonist
abdominal discomfort and pain, flatulence, diarrhea; anemia, hypokalemia, back pain, urinary retention; Caution severe hepatic impairment, ESRD |
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Term
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Definition
chronic opioid-induced constipation
MOP receptor antagonist
dizziness, nausea, abdominal discomfort and pain, flatulence, diarrhea; caution severe NVD abdominal pain, avoid in GI obstruction |
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Term
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Definition
chronic idiopathic constipation
chloride-channel activator
headache, nausea,abdominal pain, distension, diarrhea; caution avoid if GI obstruction or severe diarrhea, avoid in pregnancy |
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Term
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Definition
diarrhea; high output ileostomy
opioid agonist at the GI tract
NV, dry mouth, abd discomfort, constipation; avoid if infectious etiology suspected |
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Term
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Definition
sev diarrhea-predominant IBS in women
5HT 3-receptor antagonist
nausea,,,p; abd discomfort, constipation; avoidif h/o IBD, constipation, obstruction, stricture, adhesions, ischemic bowel, hypercoagulable state; caution ischemic colitis, constipation |
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Term
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Definition
pain assoc with functional bowel disorder
(anticholinergic) muscarinic receptor antagonist at enteric plexus and smooth muscle
dry mouth, visual disturbances, urinary retention, constipation; interaction with other anticholinergic agents |
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Term
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Definition
GERD, GU, DU, other hypersecretorystates
reduces HCl secretion from parietal cells by inhibiting H +-K +-ATP-ase activity
Headache, dizziness, somnolence, GGI complaints; hypergastrinemia, vitamin B 12 deficiency; myopathy, arthralgia; absorption of ketoconazole, effect of clopidogrel |
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Term
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Definition
GERD, GU, DU, other hypersecretory states
reduces HCl secretion from parietal cells by blocking H 2 receptors
headache, somnolence, fatigue, dizziness, constipation/diarrhea; rare confusion or other mental status changes |
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Term
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Definition
Mucosal surface protection
Blocks pepsin action; local PG stimulation
Advantage: Non-absorbed (Al-salt of sucrose-octasulfate)
Dry mouth, nausea, constipation, hypophosphatemia Caution in gastroparesis
Disadvantage: Aluminum absorption possible in CKD patients Requires pH < 4 for optimal action |
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