Term
| Histamine Type - 2 Blocker Names |
|
Definition
| Climetidine, Ranitidine, Famotidine, Nizatidine |
|
|
Term
| H-2 Receptor Antagonists MOA |
|
Definition
| Reversibly inhibit H2-receptors on the basolateral membrane of parietal cells |
|
|
Term
| H2 Receptor Antagonist AE |
|
Definition
| GI, high dose in elderly: CNS (confusion, slurred speech, hallucinations), Cimetidine: (gynecomastia and galactorrhea), blood dyscrasias |
|
|
Term
| H2 Receptor Antagonist DI and Contraindications |
|
Definition
| CYP450, can inhibit absorption of agents via increase in gastric pH, reduce dose in renal compromise, caution in pregnancy |
|
|
Term
| Proton Pump Inhibitors Names |
|
Definition
| Omeprazole, Lansoprazole, Pantoprazole, Rabeprazole, Esomeprazole |
|
|
Term
| Proton Pump Inhibitors MOA |
|
Definition
| Acid-labile pro-drugs, go into parietal cells and can't get out, more effective than H2 receptor blockers and antacids |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Omeprazole -CYP450, can inhibit absorption of agents via increase in gastric pH, reduce dose in hepatic dz, pregnancy C for omeprazole, B for all others |
|
|
Term
| Sucralfate (Carafate) MOA |
|
Definition
| inhibit ulcerations and mucosal erosion by inhibiting pepsin-mediated hydrolysis of mucosal proteins, makes polymer that sticks to ulcer, also stimulate local prostaglandin production and epidermal growth factor, does not affect pH |
|
|
Term
| Sucralfate AE/Contraindications |
|
Definition
| Constipation, Renal failure |
|
|
Term
| Misoprostol (Cytotec) MOA |
|
Definition
| A prostaglandin E1 analog, provides protective prostaglandins to gastric mucosa, stimulates bicarb and mucous production, increases mucosal blood flow, decreases pepsin |
|
|
Term
| Misoprostol AE/Contraindications |
|
Definition
| Mainly GI, Pregnancy (unless used in off label), IBD |
|
|
Term
|
Definition
Increases production of bicarb and mucous and may bind to ulcer site, also antibacterial actions |
|
|
Term
| Bismuth AE/DI/Contraindications |
|
Definition
| Constipation, Black stools, LOTS DI, Children/Pregnancy, Antiplatelets/Anticoagulants, Diabetics, Renal failure |
|
|
Term
| Metronidazole (Flagyl) MOA |
|
Definition
| Pro-drug activated by electron transfer process creating nitro radicals which kill organism |
|
|
Term
| Metronidazole AE/DI/Contraindications |
|
Definition
| Dry mouth, N/V/D, metallic taste, disulfiram-like reaction, induces metabolism of rifampin and anti-seizure meds, alcoholic beverages, CNS dz, hepatic dz, 1st trimester pregnancy |
|
|
Term
| Triple Therapy for H. pylori |
|
Definition
| A PPI, Clarithromycin, Amoxicillin or Metronidazole |
|
|
Term
| Quadruple Therapy for H. pylori |
|
Definition
| A PPI or H2 receptor blocker, Metronidazole or Clarithromycin, Amoxicillin or Teracycline, Bismuth |
|
|
Term
|
Definition
|
|
Term
| H. pylori w/ metronidazole resistance |
|
Definition
| substitute tetracycline, consider quadruple therapy |
|
|
Term
| H. pylori with clarithromycin resistance |
|
Definition
| substitute either amoxicillin or tetracycline, consider quadruple therapy |
|
|
