Term
|
Definition
Used to rx AI DO (Crohn's, UC)
Chimeric monoclonal Ab directed at TNFa
Single i.v. may induce remission in Crohn's |
|
|
Term
|
Definition
high cost
long term effects unknown |
|
|
Term
|
Definition
|
|
Term
| Loperamide considerations |
|
Definition
Use no more that 48 hrs
Can cx CNS dep in overdose
Children may be more sensitive to CNS effects |
|
|
Term
|
Definition
acts at mu rec
50 times more potent than morphine at antidiarrheal, but low abuse potential |
|
|
Term
|
Definition
|
|
Term
|
Definition
Dopamine receptor antagonist
Prokinetic |
|
|
Term
|
Definition
|
|
Term
|
Definition
Antiemetic rx
Blocks DA rec in CTZ |
|
|
Term
| Metoclopramide adverse effects |
|
Definition
CNS effects
Tardive dyskinesia |
|
|
Term
|
Definition
Inc tone of LES
Stimulate antral and sm int contractions
Facilitates gastric emptying |
|
|
Term
|
Definition
1. Gastroparesis
2. Postoperative ilius
3. N/V cxed by dymotility |
|
|
Term
|
Definition
|
|
Term
| Misoprostol adverse effects (3) |
|
Definition
1. Diarrhea
2. Exacerbates IBD
3. Abortion |
|
|
Term
|
Definition
Binds to EP3 rec on parietal cells and inh acid secretion
Stim secretion of mucin and bicarb |
|
|
Term
| Misoprostol pharmacokinetics |
|
Definition
First-pass
Food and antacids delay absorption
Effective w/in 30 min, lasts 3 hrs |
|
|
Term
|
Definition
| 1. Prevent NSAIDs mucosal inj |
|
|
Term
|
Definition
| 5-aminosalicylate w fewer adverse affects than sulfsalazine |
|
|
Term
|
Definition
|
|
Term
|
Definition
1. Heal gastric ulcers
2. GERD
3. ZOllinger-Ellison
4. Reduce duodenal ulcer recurrence |
|
|
Term
|
Definition
Antiemetic
Blocks 5HT rec in CTZ |
|
|
Term
|
Definition
| Selective anatagonist of 5HT rec |
|
|
Term
| Ondansetron indications (2) |
|
Definition
1. N/V of chemo, radiation
2. Post-op N/V |
|
|
Term
| Ondansetron pharmacokinetics |
|
Definition
| Antiemetic effects persist long after drug is gone |
|
|
Term
| Ondansetron side effects (3) |
|
Definition
Allergic rxns
COnstipation/diarhea
Fever, HA |
|
|
Term
|
Definition
1. Hypergastrinemia
2. Dec B12 absorption
3. Inh CYP450 |
|
|
Term
|
Definition
|
|
Term
| Proton pump inh mechanism |
|
Definition
Inh K/H ATPase
Exist as prodrugs, absorbed in systemic circulation, accumulate in parietal cell canalicul
Binds irreversibly w -SH groups on the pump
Inh 95% acid secretion |
|
|
Term
| Proton pump inh pharmacokinetics |
|
Definition
Delayed realease oral forms enteric coated to bypass gastric acids
Elimination time 1-2 hrs, but effective 12-24 hrs
Administer w or before meals
Takes several doses to achieve max suppression |
|
|
Term
|
Definition
Highly effective
Inexpensive
Short duration
Causes alkalosis w excessive use |
|
|
Term
|
Definition
| 5-aminosalicylate used in IBD |
|
|
Term
| Sulfasalazine considerations |
|
Definition
Many adverse effects, so...
Not preferred
1. Megaloblastic anemia
2. Low sperm ct
3. Steven-Johnson synd
4. Pancreatitis
5. Neurotox |
|
|
