Term
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Definition
Artropine (Donatel), Propantheline (ProBanthine), Metantheline Bromide - Mech: Dcrs gastric acid production by blocking parasympathetic signals to parietal cells
- Adverse: Vagotomy effect: dry eyes/mouth, blurred vision, atony of bladder/intestine (constipation), flushing.
- Contraindic'd in case of pyloric stenosis, hiatal hernia
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Term
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Definition
Ranitidine (Zantac), Cimetidine (Tagamet), Nizatidine (Axid), Famotidine (Pepsid) - Mech: Dcrs gastric acid prod'n by blocking histamine rcptr on parietal cells
- Prophylactic/long-term use to prevent ulcers
- Adverse: Uncommon HA, lethargy, Cytochrome p450 interaction (Cimetidine<Ranitidine) =affects warfarin, dilantin, lidocaine metabolism
- REBOUND HYPERACIDITY - discontinue slowly
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Term
H+/K+ATPase Inhibitors (PPI's) |
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Definition
Omeprazole, Pantoprazole, Rabeprazole, Lansoprazole, Esomeprazole - Mech: Dcrs acid secretion by blocking H+ pump
- Slower onset, but more acid inhibition than H2 Rcptr antags
- Adverse: HA, gynecomastia, p450 inhibition (dcrsd clearance of warfarin, diazepam, dilantin)
- No long-term treatment: gastric carcinoma in animals
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