Term
What hepatitis viruses are spread by the fecal-oral route
Which has no carriers, no chronic disease, and no carcinoma risk |
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Definition
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Term
What are the presentations of Hep B?
What age group develops the most chronic infections with Hep B? |
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Definition
Presentations
Acute
Fulminant
Chronic
Age Group: Neonates |
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Term
| What is required for hepD infection |
|
Definition
|
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Term
| What is the most common cause of Chronic Hepatitis and hepatocellular Carcinoma |
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Definition
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Term
| Histology of acute viral hepatitis |
|
Definition
Disarray(Structure)
Necrosis with Ballooning degeneration
Inflammation(past limiting plate)
Regeneration(binucleate cells) |
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Term
| What does grade and stage describe in chronic hepatitis |
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Definition
Grade: level of...
Necrosis
Lobar activity
Portal inflammation
Stage:
Severity of fibrosis None->Portal->Bridging->Cirrhosis |
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Term
What are the pathological stages of alcoholic fatty liver disease and the pathology of each?
What zone does it start in? |
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Definition
Fatty Liver: zone 3
Alcoholic Steatohepatitis:
necrosis
inflammation
mallory hyaline
perivenular fibrosis
Cirrhosis: thick bridging fibrosis |
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Term
| What is the pathogenesis of alcoholic steatosis? |
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Definition
Increased Fatty Acid Synthesis
Decreased Beta oxidation
Increased Triglycerides
Impaired lipoprotein release
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Term
What is the cause of primary biliary cirrhosis?
What are the pathological stages?
What are the markers?
What sex is it more common in?
What other diseases it it seens with |
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Definition
Autoimmune disease more common in women
Markers: Anti-Mitochondrial, Elevated IgM
Associations: 85% have another autoimmune disease
Stages
I: Granulomas, small and medium duct destruction, inflammation
II: Periportal inflammation
III: Bridging Fibrosis
IV: Cirrhosis |
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Term
What disease is primary sclerosing cholangitis associated with?
What antibody is seen?
What is the risk?
What sex is affected?
What are the pathological Features |
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Definition
Ulcerative Colitis
P-ANCA
Cholangiocarcinoma
Males
Pathology
Activity near bile duct
Onion Skining Fibrosis |
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Term
What is the cause of Hereditary Hemochromatosis and
What are the major signs
What is the HLA association? |
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Definition
AR HFE gene(chromosome 6) mutation linked to HLA-A3
Signs
Skin Pigmentation
Diabetes
Cirrhosis and Hepatocellular Carcinoma
Chondrocalcinosis of MCP and PIP
Dialated Cardiomyopathy
Infections: Vibro, Yersina, Listeria |
|
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Term
What is wilson's disease?
What are the major signs? |
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Definition
AR in Cu-atpase on chromosome 13
Signs
KF lesions
Cirrhosis
Neurological Signs
Fanconi Syndrome |
|
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Term
| How does CF effect the liver of a neonate |
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Definition
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Term
What is the most common genetic cause of liver disease in infants and children?
What are the liver manifestations?
What is seen pathologically?
What forms cause emphysema and liver cirrhosis? |
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Definition
Alpha-1 anti-trypsin deficiency
Manfestations
Hepatitis
Cholestasis
Hepatocellular carcinoma
Pathology: PAS(+) inclusion bodys
Emphysema: PiSZ, PiSS
Cirhosis: PiZZ |
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Term
| what people are particularly suseptible to Hep E |
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Definition
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Term
What sex is autoimmune hepatitis common in?
What anti-bodies are associated with the disease? |
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Definition
Women
Anti-SM, ANA, Increased IgG |
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Term
| What are some causes for NAFL or NASH |
|
Definition
Diabetes
Obesity
Corticosteroids
Kwashiorkor |
|
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Term
What are the serological markers of the following diseases?
Celiac Sprue
Autoimmune Hepatits
PBC
PSC
GIST tumor
Hepatocellualar Carcinoma
Pancreatic Cancer |
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Definition
Anti-tTG
Anti-SM, ANA, and Elevated IgG
Anti-Mitochondrial and high IgM with
P-ANCA with Jaundice
cKIT
alpha-Fetoprotein
CA19-9 and CEA |
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