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GI Hormones
Main hormones
15
Physiology
Graduate
04/14/2008

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Cards

Term
CCK
Definition
D,J- secreted by I cells-Stimulates GB contr, Panc enzy & bicarb secr, growth of exocrine panc, INHIBITS Gastric emptying
Term
Gastrin
Definition
Antrum- stimulates Gastric acid secretion
Term
Secretin
Definition
D- Stim pan. bicarb, pepsin secr, exocrine panc growht INHIBITS gastric acid secr.
Term
GIP
Definition
D,J- -released by K cells-stim insulin release INHIBIT gastric acid release
Term
Motilin
Definition
D,J- stim gastric & intest motility
Term
hormones found in brain as well
Definition
gastrin & cck
Term
Paracrine hormones
Definition
Somatostatin (directly inhibits acid secr from parietal cells), Histamine (not peptide, but regulates gastric acid secretion)
Term
Inhibitor of somatostatin
Definition
Vagal activation & high pH
Term
Neurocrine hormones
Definition
VIP, GRP (Bombesin), Enkephalins
Term
Somatostatin
Definition
Inhibits all gut hormones (gastrin, peptide and acid prod)
Term
Histamine fn? mainly prod by?
Definition
STIMULATES gastric acid secr via parietal cells--prod by Enterochromaffin-like cells
Term
VIP
Definition
Vasoactive Intestinal Peptide--relaxes GI smooth muscle & sphincters--maybe NO release--weak stim of bicarb and liquid secr from pancreas & intest mucosa
Term
GRP/ Bombesin
Definition
Gastrin Releasing Peptide- released by vagal stimulation- causes G cells to secr gastrin--
Term
Enkephalins
Definition
(opiates bind same receptors) 2 forms: met and leu--Contract SM, inhibit GI liquid secretion-reduces GI motility and secretion-- CAUSE CONSTIPATION!!
Term
Non-Ach mediated acid causing agent?
Definition
Gastrin Releasing peptide/ Bombesin
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