Term
| What are the DEFENSIVE factors that prevent peptic ulcer disease? |
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Definition
| Mucus, Bicarb, blood flow, prostoglandins |
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Term
| What are the AGGRESSIVE factors that cause peptic ulcer disease? |
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Definition
| h. pylori, pepsin, gastric acid, NSAIDS, smoking |
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Term
| What is the role of h pylori in PUD? |
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Definition
| a gram neg bac that evades stomach acid by hiding btw the mucus layer and the cells in stomach and duodenum |
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Term
| What are the goals fo drug therapy in PUD? |
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Definition
| Prevention, alleviate sx, promote healing, prevent complications |
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Term
| What are the 4 classes of anti-ulcer drugs used to treat PUD? |
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Definition
| Antibiotics, antisecretory agents (H2R's, PPI's (proton pump ihi)), Mucosal Protectants, Antacids |
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Term
| What receptors and compounds involved in gastric acid stimulation and secretion in the parietal cell? |
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Definition
| Muscarinic (ACh), H2 (HIST), Prostoglandin (PG's), Gastrin |
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Term
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Definition
| H2RA [Gastric duodenal ulcers, GERD, Z-Ellison Synd, Aspiration Pneumonitis, Heartburn, Acid Indg, Sour Stomach] Antiadndrogenic effects like gynecomastia, confusion/hallucinations, Pneumonia |
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Term
| Proton Pump Ihi (Omeprazole) Enteric Coated. |
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Definition
| Gastric and duodenal Ulcers and GERD--PRODRUG, irrev ihi K/H, ATPase pump that generates all gastric acid 97% w/in 2 hrs [Headache, diarrhea, nausea, vomiting] |
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Term
| Sucralfate (class not specified?) |
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Definition
| Forms protective barrier allowing ulcer to heal (up to 6 hrs) [acute ulcers (st tx] administer 30-60' before eating, not absorbed (good for liver diseased pts) {Constipation} Can bind to other meds. |
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Term
| What are the side effects of Mg in antacid? Aluminum? |
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Definition
| Mg=diarrhea, Al=constipation |
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