Term
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Definition
- Antibodies develop 2-3 wks, booster 6-12 months after initial dose.
- Indicated in travelers, health care providers, military personal, populations at high risk
- IM immunoprophylaxis
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Term
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Definition
| Recombinant vaccine. Three IM injections. Booster not recommended unless immunosuppressed. If exposed, give vaccine of antibody levels are <10 mIU/ml |
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Term
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Definition
Used for chronic hep B. Nucleoside analog activated in vivo. Requires lower doses than HIV due to higher effect.
Competitively inhibits HBV reverse transcriptase, causes termination after incorporation. |
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Term
| Entecavir and telbivudine |
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Definition
Nucleoside analogue of guanosine
Used in chronic HBV, inactive against HIV. Lower incisdence of drug resistance, with higher effectivity compared to lamivudine and adefovir |
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Term
| What is the standard treatment for HCV? What are some factors associated with favorable response? Side effects? Counter indications? |
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Definition
- Pegylated interferon alfa 2b and ribovarin
- HCV genotype 2 and 3, abscence of cirrhosis, low pre-treatment HCV RNA levels
- Flu like symtpoms within 6 hours; thrombocytopenia, granulocytopenia, high neuropsychiatric effect
- Psychosis, depression, neutropenia, decompensated cirrhosis, uncrontrolled seizures, organ transplant
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Term
| Dicyclomine and hyosycamine |
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Definition
Anti-spasmodics (anticholinergic) for diarrhea-related IBS
Used infrequently due to side effects (dry mouth, visual iurbance, urinary retention) |
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Term
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Definition
Used for diarrhea releated IBS. Serotonin antagonist. Longer duration than other 5-HT3.
SEVERE side effects (constipation in 30%), ischemic colitis (0.3%) |
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Term
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Definition
| Partial 5-HT4 agonist (resembles serotonin). Used in constipation IBS. Relieves pain and stimulates peristalsis. Well-tolerated. |
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Term
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Definition
| Bile acid used to treat gallstones. Dissolves small cholesterol gallstones. |
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