MOA: after reduced it reacts w DNA --> damage and death of org

USE: H. pylori, C.diff, trichomonas, anaerobes, amebiasis, giardiasis

Toxicity: disulfiriam like effect: abdomen distress, metallic taste, headache

MOA: Interferes w ETC (essential for anaerobes)

Toxic: eye and urine turn yellow

USE: cryptosporidiosis and giardiasis

MOA: Aminoglycoside binds to 30s subunit and inihibits protein synthesis

Use: E. histolytica

MOA: inihibits microtubule polym therefore degen changes in intestinal cells of helminths --> immobilization and death of parasite

**used for mass deworming programs**

MOA: inihibits microtubule polym thereofre degen changes in intestinal cells of helminths --> immobilization and death of parasite

USE: STH, hookworm, enterobiasis, ascariasis, trichuriasis

FYI: take with fatty meal for tissue parasite

take with empty stomach for intraluminal parasite

MOA: inihibits microtubule polym thereofre degen changes in intestinal cells of helminths --> immobilization and death of parasite

USE: enterobiasis, ascariasis, hookworm, trichuriasis

FYI: chewable and take w fatty meal

MOA: inihibits microtubule polym thereofre degen changes in intestinal cells of helminths --> immobilization and death of parasite

USE: cutaneous larva migrans, strongyloidasis

FYI: Chewable and topical forms

MOA: constant ach released - causes tonic paralysis in helminth so they can't attach

Use: Ascariasis (pinworm), enterobiasis

IMP: OTC in US for pinworm! treat entire family

take 1g once orally

Use: riverblindness, head lice, scabies, mass deworming

FYI: single dose, clears microfilaria from skin

does NOT destroy adult worms --> must repeat every 6-12months for up to 10years

Take on empty stomach

MOA: increases parasites cell membrane permeability to calcium --> causes tonic paralysis in worms

Use: schistosomiasis (mass deworming), tapewom