Term
What is the prevalence of heartburns among Americans monthly? weekly? daily?
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Definition
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Term
| What is the baseline pressure at the lower esophageal sphincter? |
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Definition
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Term
| What's the prevalence of the hiatal hernia |
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Definition
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Term
| What percentage of GERD patients have TLESR as their primary mechanism? |
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Definition
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Term
| T or F: H. pylori exacerbates GERD |
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Definition
| False- It has a protective effect |
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Term
| What % of GERD patients actually have an erosive esophagitis condition? |
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Definition
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Term
| What is the most commonly accepted definition of gastroesophageal reflux? |
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Definition
| sudden decrease in intraesophageal pH to below 4.0, with the nadir pH being reached within 30 seconds from the beginning of the drop |
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Term
| What is the extent of healing reflux esophagitis directly related to? |
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Definition
| the duration of intragastric pH> 4 |
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Term
| What is the primary mechanism of H2 blockers in reducing gastric acid secretion? |
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Definition
| They inhibit the signal transduction that leads to the secretion of HCl into the gastric lumen |
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Term
| Ulcers beyond the bulb of the duodenum are commonly due to what disease? |
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Definition
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Term
| What is the causal agent of peptic ulcer disease? |
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Definition
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Term
| With pan-gastritis, do you have a bigger risk of getting a gastric ulcer or a duodenal ulcer? |
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Definition
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Term
| What is the advantage of Cox2 NSAID's over regular NSAID's? |
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Definition
| They avoid prostaglandin synthesis that mediates inflammatory and tissue damage processes. |
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Term
| What is the common age onset for individuals with IBD? |
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Definition
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Term
| Smoking may be a protective in which IBD? |
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Definition
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Term
| Moderate UC entails involvement of the colon up to what point? |
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Definition
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Term
| At what point does UC necessitate blood transfusion? |
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Definition
| When it's considered severe-- extensive colonic involvement with daily bloody stools |
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Term
| For moderate UC disease, what's the state of the abdomen and fever status? |
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Definition
| there's abdominal pain, but it's not severe/ there is little to no fever |
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Term
| Does UC typically have a sudden or gradual presentation? |
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Definition
| gradual/ PE is often times normal |
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Term
| What are three common extra-intestinal presentations of UC? |
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Definition
| sclerosing cholangitis, uveitis, and erythema nodosum (there are others like ankylosing spondylitis and more) |
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Term
| What is the only biologic approved for UC? |
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Definition
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Term
| What percentage of CD cases have involvement of the small bowel? |
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Definition
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Term
| What effect does CD have on overall life expectancy? |
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Definition
| At worst, there is only a modest reduction |
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Term
| What sort of agents do we use to treat fistulas in CD? |
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Definition
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