Term
| prevelance of chromosomal abnormalities |
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Definition
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Term
| prevelance of single gene abnormalities |
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Definition
2% of live births 5000 types; most are rare |
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Term
| prevelance of multifactorial abnormalities |
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Definition
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Term
| prevelance of major congenital abnormalities |
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Definition
2-3% of newborns 5% by 1 year |
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Term
% of congenital abnormalities caused by: multiple factors Mendelian factors maternal factors mechanical deformation |
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Definition
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Term
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Definition
| anomaly produced by aberrant mechanical force |
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Term
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Definition
| renal ageneis (malformation) causes flat face + pulmonary hypoplasia (deformations) |
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Term
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Definition
| congenital abnormality arising due to destruction of normal tissue |
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Term
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Definition
abnormality caused by failed or incomplete embryonic process(es) ie; an interruption of normal development |
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Term
NF2 full name cause outcome |
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Definition
neurofibromatosis type II loss of 2 MERLIN alleles (inherited +spontaneous) -bilateral schwannomas -multiple meningiomas |
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Term
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Definition
| 1st full 7 weeks after fertilization |
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Term
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Definition
rest of pregnancy 8 - 38 weeks post-fertilization |
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Term
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Definition
| agent that causes malformation(s) |
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Term
requirement for: generalized embryonic toxicity tissue specific effect |
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Definition
high dose critical time of action |
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Term
outcome of teratogen exposure in weeks 1-3 |
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Definition
-miscarriage -fetal death |
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Term
outcome of teratogen exposure in weeks 3-8 |
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Definition
-major, tissue-specific malformations -growth retardation -impaired IQ -fetal death |
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Term
outcome of teratogen exposure in weeks 8-38 |
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Definition
-growth retardation -imparied IQ -stillbirth |
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Term
| week during which risk of birth defect induction is highest |
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Definition
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