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Genetics
CH1 Key Terms
55
Biology
Undergraduate 3
08/19/2017

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Term
genome
Definition
all of the chromosomes and DNA sequences that an organism or species can possess; stores genetic instructions
Term
genetics
Definition
the study of heredity and variability
Term
gene
Definition
at the molecular level, the gene contains the instructions to make RNA or a protein
Term
traits
Definition
a characteristic that an organism displays. The three categories are morphological, physiological and behavioral.
Term
nucleic acids
Definition
a macromolecule that forms RNA or DNA and is composed of repeating nucleotides; which are composed of a phosphate, a sugar and a base
Term
proteins
Definition
a functional unit composed of one or more polypeptides. Polypeptides are a sequence of amino acids that is the product of mRNA translation. One or more polypeptides fold and associate with each other to form a protein.
Term
carbohydrates
Definition
an organic molecule that is a simple or multiple sugar. The formula is a multiple of C(H2O).
Term
lipids
Definition
an organic molecule that is insoluble in water and comprises the larger % of cell membranes
Term
macromolecules
Definition
a large organic molecule composed of smaller building blocks, examples are DNA, RNA, proteins and large carbohydrates
Term
proteome
Definition
the collection of all the proteins that a given cell or species can make
Term
enzyme
Definition
a protein that functions to accelerate chemical reactions within a cell
Term
deoxyribonucleic acid (DNA)
Definition
double stranded structure that is the genetic material. Each strand is composed of repeating units of deoxyribonucleotides. Bases are A,T,C and G.
Term
nucleotides
Definition
the base unit of DNA and RNA, composed of a sugar, a phosphate group and a base (A,T,U,C or G)
Term
polypeptides
Definition
a sequence of amino acids that is the product of mRNA translation. One or more polypeptides fold and associate with each other to form a protein.
Term
genetic code
Definition
the correspondence between a codon and its functional role during translation, each sequence of three bases is a codon that codes for a particular amino acid or begins or ends translation
Term
amino acid
Definition
contains an amino group, a carboxyl group and a side chain; it is a building block of polypeptides
Term
chromosome
Definition
the structure within the living cell that contains the DNA and its structural proteins
Term
gene expression
Definition
the process by which the information in a gene is accessed, to synthesize RNA followed by proteins, to eventually affect the phenotype of the organism
Term
transcription
Definition
the process of synthesizing mRNA from the DNA template
Term
ribonucleic acid (RNA)
Definition
a nucleic acid whose composition is very similar to DNA with the exception that the Uracil base is used in lieu of the Thymine base; nucleotide sequence that is transcribed from DNA
Term
protein-encoding genes
Definition
genes that produce mRNA and encode polypeptides
Term
structural genes
Definition
protein-encoding genes
Term
messenger RNA (mRNA)
Definition
the ribonucleotide sequence that contains the instructions for the synthesis of a polypeptide
Term
translation
Definition
the synthesis of a polypeptide using the ribosome, the codon from mRNA and tRNA
Term
central dogma of genetics
Definition
DNA is transcribed to mRNA which is translated to polypeptides which make proteins
Term
morphological trait
Definition
a trait that affects the physical appearance of an organism (such as eye color)
Term
physiological trait
Definition
a trait that affects a cellular or body function (such as glucose metabolism)
Term
behavioral traits
Definition
a trait that involves behavior, such as learning
Term
molecular level
Definition
the perspective of life from the view of individual molecules (groups of bound atoms), for example how many protein molecules are in a cell
Term
cellular level
Definition
an observation made from the perspective of a cell (in an organ in an organism)
Term
organism level
Definition
the observation point that is from the perspective of the whole creature (microbe, dog or cat for example)
Term
species
Definition
a group of organisms that maintains a distinctive set of attributes in nature
Term
population level
Definition
the level of observation includes the whole set of species of an organism (or organisms capable of interbreeding) in a community
Term
alleles
Definition
an alternative form of a specific gene, which determines variation
Term
genetic variation
Definition
differences among members of the same species or among different species
Term
morphs
Definition
a form or phenotype in a population, for example red eyes versus white eyes
Term
gene mutations
Definition
a relatively small variation that affects only a single gene
Term
environment
Definition
the surroundings that an organism experiences
Term
phenylketonuria (PKU)
Definition
a human genetic disorder that arises from a defect in phenylalanine hydroxylase
Term
diploid
Definition
an organism or cell that contains two copies of each type of chromosome
Term
homologs
Definition
one of the chromosomes in a pair that derived from the same ancestral gene
Term
somatic cells
Definition
any cell in the body that is not a germ-line cell (those cells that give rise to gametes)
Term
gametes
Definition
a reproductive cell that can unite with another reproductive cell to form a zygote; normally haploid
Term
haploid
Definition
contains a single set of chromosomes; normally a reproductive cell
Term
biological evolution
Definition
the accumulation of genetic changes in a species or population over the course of many generations
Term
evolution
Definition
the changes in the genetic makeup of a population from one generation to the next
Term
natural selection
Definition
the process whereby differential fitness acts on the gene pool because if a beneficial allele is created, it may become prevalent and be passed on because those who possess it are more fit for survival
Term
model organism
Definition
an organism studied by many scientists so that the properties of the given species may be determined over time
Term
genetic cross
Definition
mating two individuals and analyzing their offspring in an attempt to understand how traits are passed from parent to offspring
Term
genetic approach
Definition
the study of mutant genes that have abnormal functions
Term
loss-of-function mutation
Definition
a change in a genetic sequence that creates a loss in physiology
Term
loss-of-function allele
Definition
a variation in a gene that encodes for an RNA or protein that is compromised in physiology
Term
hypothesis testing
Definition
using statistical methods to determine if the data from an experiment are consistent with a hypothesis
Term
scientific method
Definition
a process that scientists follow to reach verifiable conclusions
Term
discovery-based science
Definition
does not require a hypothesis; the goal is to collect data to be able to formulate a hypothesis
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