Term
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Definition
| Mutation in which one nucleotide base pair is replaced by another. |
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Term
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Definition
| An inherited large-scale change in chromosome structure or number. |
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Term
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Definition
| Mutation whose phenotype is expressed only in particular environmental conditions. |
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Term
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Definition
| Mutation in which one or more base pairs is absent. |
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Term
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Definition
| A mutation that converts a wild type allele into a new allele. |
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Term
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Definition
| An addition or deletion of one or two nucleotide base pairs to the coding region of a gene, resulting in the remainder of the coding sequence being read in a new and incorrect reading frame. |
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Term
| Gain-of-function mutation |
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Definition
| A mutation that increases production of a gene product or produces a gene product in cells where it should not be produced, producing a qualitatively new phenotype. |
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Term
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Definition
| An inherited change in the nucleotide sequence of DNA within a single gene; i.e., the conversion of one allele of a gene into a different allele. |
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Term
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Definition
| Increase in severity of a genetic disease as it passes from generation to generation, due to expansion of trinucleotide repeats. |
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Term
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Definition
| A mutation that occurs in a reproductive cell and can be transmitted to the next generation through the gametes. |
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Term
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Definition
| A mutation that results from intentional exposure to a mutagen. |
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Term
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Definition
| Mutation in which one or more extra nucleotide base pairs is present. |
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Term
| Loss-of-function mutation |
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Definition
| A mutation that reduces or eliminates the function of a gene product. |
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Term
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Definition
| A mutation in the coding sequence of a gene that changes a codon for one amino acid into a codon for a different amino acid. |
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Term
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Definition
| Any physical or chemical treatment that increases the rate of mutations. |
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Term
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Definition
| A stably inherited change in the nucleotide sequence of DNA. |
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Term
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Definition
| A mutation in the coding sequence of a gene that changes a codon for an amino acid into a stop codon. |
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Term
| Reverse mutation (reversion) |
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Definition
| A mutation that restores a mutant allele to the wild type. |
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Term
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Definition
| A mutation that occurs in a cell that is not part of the germ line. |
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Term
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Definition
| A mutation that arises naturally in the absence of intentional exposure to a mutagen. |
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Term
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Definition
| A second mutation at a different site that restores the normal phenotype in combination with a first mutation. |
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Term
| Synonymous (silent) mutation |
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Definition
| A mutation in which a codon is changed to another codon that encodes the same amino acid. |
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Term
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Definition
| A mutation in which a purine is replaced with a purine or a pyrimidine is replaced with a pyrimidine. |
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Term
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Definition
| A DNA sequence that can move from one position to another within or between DNA molecules. |
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Term
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Definition
| A mutation in which a purine is replaced with a pyrimidine or a pyrimidine with a purine. |
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