Term
| Types of studies used to determine genetic component of diseases |
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Definition
1. Family studies
2. Twin studies
3. Adoption studies |
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Term
| Type of study used to determine transmission |
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Definition
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Term
| Type of study to locate corresponding genes |
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Definition
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Term
| Type of study to determine contribution to disease |
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Definition
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Term
| What is Mendel's 1st law? |
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Definition
| Law of segregation. When a gamete is formed, for any pair of characteristics there is only 1 gene in the gamete |
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Term
| What is Mendel's 2nd law? |
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Definition
| Law of independent assortment. Alleles of different genes assort independently of one another during gamete formation |
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Term
| What are violations to the Hardy-Weinberg law? |
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Definition
1. Non random mating
2. Mutation
3. Selection
4. Migration
5. Genetic drift |
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Term
| What is the premise of family studies? |
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Definition
| That trait resemblances should increase w/increasing degree of genetic relatedness |
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Term
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Definition
| The % agreement in trait values among pairs of relatives |
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Term
| What is pairwise concordance? |
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Definition
| The # of concordants/ total # of pairs |
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Term
| What is probandwise concordance? |
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Definition
| # probands in concordant pairs/#probands in concordant pairs + probands in discordant pairs |
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Term
| Which type of of concordance is preferred? |
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Definition
| Probandwise since it provides an estimate of risk |
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Term
| What is the premise of twin studies? |
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Definition
| Any difference in a trait between the two types of twins must be due to genetic factors |
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Term
| What are limitations to twin studies? |
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Definition
1. Placentation
2. Diff. parental treatment
3. Diff. environmental exposures |
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Term
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Definition
| Proportion of the variance in the phenotype that is due to genetic differences among individuals |
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Term
| What is the premise of adoption studies? |
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Definition
| A natural experiment to disentangle genetic & environmental sources of familial resemblances |
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Term
| What is the adoptees study method? |
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Definition
| Sample affected and unaffected parents and compare rates in adopted away children |
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Term
| What is the adoptees family method? |
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Definition
| Sample affected and unaffected adoptees and compare rates in biological and adoptive families |
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