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Genetics Unit 1
Mendelian Genetics
59
Biology
Undergraduate 3
02/03/2014

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Term
Mitosis
Definition
Clonal process that duplicates a cell into 2 daughter cells
plays the role of organismal growth and repair
Preserves genetic continuity within the individual
Term
Meiosis
Definition
restricted by area
produces non identical daughter cells
promotes variability
Term
G1
Definition
Mitosis phase where growth and doubling of ribosomes returns cell to normal size
Term
S Phase
Definition
Replication of Genetic Material
4N or tetraploid
Term
heterozygous
Definition
a chromosome has different alleles at identical loci.
Aa
Term
homozygous
Definition
a chromosome that has identical alleles at the loci
AA or aa
Term
Prophase (mitosis)
Definition
condensation of genetic material, allowing for movement
centriole divides and migrates to poles forming spindle/microtubules
Term
Metaphase (mitosis)
Definition
Homologous chromosomes line up at the equator of cell
unique from meiosis b/c homologous pairs are separate
Term
Anaphase (mitosis)
Definition
separation of homologous by centromere ratcheting on microtubule
Term
Telophase (mitosis)
Definition
reversal of prophase and decondensation of chromosomes and dissolution of spindle
reformation of nuclear membrane
Term
Cytokinesis (mitosis)
Definition
breakup of cells by cleavage
plasma membrane is pulled in
Term
Meiosis I
Definition
5 subphases that cover condensation, spindle formation, and membrane dissolution
Leptonema
Zygonema
Pachynema
Diplonema
Diakinesis
Term
Leptonema
Definition
condensation begins and small buds (chromomeres) form chromosomes
some regions condense quicker than others
Term
Zygonema
Definition
synapsis occurs during the pairing of homologues
end of pairing signals end of subphase
Term
Pachynema
Definition
homologues are held together at synaptonemal complex w/ protein
crossing over can occur
Term
Bivalent
Definition
homologous pair that is physically bonded
each homologue has 2 sister chromatids
exchange of material must be between non sisters
creates 4 unique chromosomes
Term
Diplonema
Definition
dissolution of synaptonemal complex, allowing chromosomes to move
chiasma (crossing over location) observable
enhanced by condensation
Term
Diakinesis
Definition
continued condensation
termination of chiasmata
spindle tugs slightly
Term
Metaphase I
Definition
same as mitosis, but homologues are not independent
Term
Anaphase I
Definition
no centromeric replication
spindle fibers pull to poles
homologues are being separated, creating unique daughter cells
Term
Telophase I
Definition
nuclear membrane reforms, decondensation
can be skipped
Term
Primary Meiocyte
Definition
A cell after S phase
chromosomally 2N
DNA amount is 4N
Term
Secondary Meiocyte
Definition
A cell after Meiosis I
Chromosomally haploid (N)
DNA diploid 2N
Term
Spermatid/Ootid
Definition
after Meiosis II
completely haploid
Term
Dyad
Definition
sister chromatid that shares a centromere
half of a bivalent
Term
Monad
Definition
Haploid Chromosomes (after MII)
Term
Statistics Rules
Definition
Random events with independent loci that are heterozygous
2^N genetically possible outcomes
Term
Mendelian Postulates
Definition
Unit factors are deterministics
UF occur in pairs
UF are dominant or recessive
each parents contributes only 1 UF
UF selection is random
Term
Heterozygous Dihybrid cross ratio
Definition
9:3:3:1
Term
Multiallelic
Definition
example of human blood type
Term
Epistasis
Definition
Interaction between alleles of different loci
Term
Simple recessive epistasis
Definition
9:3:4 where masking takes place
example of agouti mice where dominant A allowed for color, and recessive a masked color
Allele b determined agouti or Black
Term
Double Recessive epistasis
Definition
9:7
masking by ANY recessive homozygous pair
Term
Simple Dominant Epistasis
Definition
12:3:1
masking by one dominant single allele
Term
Double Dominant Epistasis
Definition
15:1
any single dominant Allele masks recessive
Term
Recessive Lethality
Definition
the phenotype is dominant for lethality, but recessive in the genetics.
Heterozygous survives, but homozygous dominant dies
Term
Types of determination
Definition
Genetic
Chromosomal
Term
Fixed Gene Sex Determination
Definition
gene determines the sex
Term
Facultative Gene Sex Determination
Definition
environment determines sex
Term
Chromosomal Determination of Sex
Definition
Change in #, Change in ploidy, Chromosomal heteromorphism
Term
Chromosomal Heteromorphism
Definition
XX,XY where males are hetero, females homo
ZZ,ZW where males are homo, females are hetero
Term
Heteromorphic
Definition
difference in size and shape between the sex chromosomes
male chromosome is hemizygous, where the male chromosome is haploid at one locus
Term
Metacentric
Definition
centromere is in the center of the chromosome. Equal length arms
Term
Submetacentric
Definition
long and short arm are skewed
Term
Telocentric
Definition
chromosomes with a terminal centromere, or only 2 arms instead of 4
Term
Sex Linkage
Definition
Determination that deals with Sex chromosomes only
differentiate this from sex limited or sex influence by doing reciprocal cross
Term
Reciprocal Cross
Definition
Performing the same genetic cross but with the sex of the parents reversed
Term
Sex Influenced
Definition
The dominance of a certain characteristic is reversed with sex. Horns/No horns with male/female bovine
Term
Sex Limited
Definition
Expression in one sex, but not in the other. Feathering of cocks and chickens.
Term
Polygenic Inheritance
Definition
multiple loci affect the phenotype
yields continuous variation
Additive and non additive
Term
Additive alleles
Definition
contribute to the phenotype with roughly equal weight
Term
Non additive alleles
Definition
do not contribute to the phenotype
Term
Pleiotropy
Definition
1 locus affects multiple characteristics
Term
Attavism
Definition
sudden reappearance of ancestral phenotypes
Term
Autosomal Linkage
Definition
This means that many loci are inherited together. This reduces the # of combos
Term
Complete Linkage
Definition
100% Parental genes, no crossing over
Term
Incomplete Linkage
Definition
give 2 parental genes and 2 recombinants
Term
Delinked
Definition
Linkage is masked by crossover frequency
any crossover between A&B affects C
the closer together genes are, the less frequent the effect
Term
Recombination Mapping
Definition
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