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Genetics Midterm Definitions
Genes to Genomes:Chapter 2-5, Mendelian Principles & Chromosome Linkage, Recombination, and Mapping
42
Biology
Undergraduate 3
10/24/2010

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Term
monohybrid cross
Definition
crosses of hybrids for a single trait
Term

 

 

allele

Definition
alt. forms of a gene
Term
mendels law of segregation
Definition
two alleles for each gene separate independently during gamete formation, and then combine, at random, one from each parent, at fertilization
Term
testcross
Definition
mating an individual with a dominant phenotype Y- with an homozygous recessive phenotype individual yy
Term
dihybrid
Definition
two pairs of alleles segregate into a heterozygous individual for two genes at the same time
Term
law of independent assortment
Definition
during gamete formation, different pairs of alleles segregate independently of one another
Term
gamete
Definition
reproductive cells containing one copy of each gene
Term
gene
Definition
heritable entity that determines a characteristic
Term
genotype
Definition
the alleles and individual has
Term
multifactoral
Definition
traits determined by two or more factors

ex: multiple genes or genes interacting with the environment
Term
incomplete dominance
Definition
hybrid F1 does not resemble either pure breeding parent, often express a phenotype intermetiade between pure breeding parents. both alleles contribute to F1 phenotype
Term
codiminance
Definition
both traits show up equally in the heterozygote's phenotype, neither parental allele is dominant or recessive to another.
Term
multiple allelesA,
Definition
a gene may have more that two alleles in the population, but an individual can only contain two forms of that alleles.

ex. IA,IB,i
Term
dominance series
Definition
alleles are listed in order from most dominant to most recessve
Term
mutations
Definition
alterations of genetic material
Term
wild type allele (+)
Definition
an allele whos frequency is greater that 1%
Term
allele frequency
Definition
each allele of a gene over the total number of gene copies.
Term
mutant allele
Definition
an allele with a frequency of less than 1%
Term
pleiotropy
Definition
phenomenon of a single gene determining a number of distinct and seemingly unrelated characteristics
Term
recessive lethal allele
Definition
an allele that negatively affects the survival of a homozygous of the recessive trait
Term
complementary gene action
Definition
two genes work together to produce a certain trait and dominant alleles of both genes must be present to produce this trait
Term
epistasis
Definition
the interaction where the allele of one gene mask the effects of the allele of another gene
Term
heterogeneous trait
Definition
a mutation that any number of genes can give rise to the same phenotype

ex:deafness
Term
complementation test
Definition
Test determining whether a phenotype arises from mutations in the same gene or seperate genes. When what appears to be an identical recessive phenotype appears in two different breeding lines we want to know if its from the same gene.

They set up mating between two lines, if offspring are wildtype unaffected, complementation has occured. If offspring express mutant phenotype it is probably from the same gene.
Term
penetrance
Definition
how many members of a population with a particular genotype show the expected phenotype
Term
modifier genes
Definition
alter phenotypes produced by the alleles of other genes
Term
conditional lethal
Definition
a type of allele that i lethal only in certain conditions

ex: a mutation that is temperature dependent
Term
homologous chomosomes
Definition
chromosomes that match in size, shape, and banding
Term
autosomes
Definition
the 44 chromosomes found in matching pairs
Term
sex chromosomes
Definition
two distinct chromosomes providing the basis for sex determination
Term

mitosis

Definition
[image]
Term
meiosis I
Definition
[image]
Term
meiosis II
Definition
Term
synapsis
Definition
pairing of homologous chromosomes during meiosis
Term
syncytium
Definition
an animal cell containing more than one nucleus
Term
syntenic
Definition
located on the same chromosome
Term
chiasmata
Definition
regions of where non-sister chromatids of homologs cross over each other
Term
map unit
Definition
a gauge of physical distance between any two/three genes on the same chromosome/recombination frequency
Term
locus
Definition
the chromosomal position assigned to a gene
Term
chromosomal interference
Definition
a phenomenon where the number of double cross overs is less than expected because crossovers do not occur independently of one another. the occurrence of one crossover reduces the chance of another crossover in an adjacent part of the chromosome.


interference= 1- coefficient of coincidence
Term
coefficient of coincidence
Definition
a measure of interference from the ratio of frequency observed over the expected frequency
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