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Genetics Final Exam
Spring 2014
96
Biology
Undergraduate 4
03/21/2014

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Term
The information in DNA dictates the order of ____ in a _____.
Definition
amino acids; protein
Term
Under normal conditions, sickle cell anemia is considered a recessive trait in humans. In a cross between a father and mother who are both heterozygous for the gene, what is the probability that a child will have sickle cell anemia(under normal conditions)?
Definition
1/4
Term
Under normal conditions, sickle cell anemia is considered a recessive trait in humans. In a cross between a father who has sickle cell anemia and a mother who is heterozygous for the gene, what is the probability that their first three children will have sickle cell anemia(under normal conditions)?
Definition
1/8
Term
in Drosophilia Virilis nuclei of somatic cells contain 12 chromosomes while nuclei of sperm cells contain only 6 chromosomes what does 2N equal for this species?
Definition
12
** if it says just N its only 6
Term
_ occurs when chromosomes fail to separate properly during meiosis
Definition
Nondisjunction
Term
In whose lab was natural transformation first noticed?
Definition
Griffith
Term
During which phase do sister chromatids segregate to opposite poles?
Definition
anaphase 2
Term
A cross between a white eyed female fruit fly and a red eye male would generate which of the following types of progeny?
Definition
Red eyed female, and white eyed males
Term
the polarity of DNA synthesis is
Definition
5' to 3'
Term
During which of the following stages of the cell cycle would a chromosome consist of only a single chromatid?
Definition
G1
Term
Which of the following statements applies to homologous chromosomes?
Definition
They contain the same genes in the same order but may have different alleles of some genes
Term
cells said to be in the G stage
Definition
are in extended G1 phase and no longer cycle
Term
the zipper like connections between paired homologs in early prophase is know as a
Definition
synaptonemal complex
Term
In drosophilia single bristled and carnation eyes are both caused by receive X linked allele. What is the value of chi sq for a test of the hypothesis that sn and car genes are unlinked? is there linkage?
Definition
2.0 no linkage (1.1+.09)
Term
The pairwise map didtances for 4 linked genes are as follows: A-B=22mu, B-c=7mu, C-D=9mu, B-D=2mu, A-D=20mu, A-C=29mu. what is the order of these 4 genes?
Definition
ADBC
Term
If you are a male, your X chromosome contains gens derived from
Definition
Both your maternal grandfather and grandmother
Term
In codominance,F1 hybrids show the traits of both parents
Definition
True
Term
A person who has type AB blood had...
A. anti-A antibodies
B. anti-B antibodies
C. Both anti-A and anti-B bodies
D. None of the above
Definition
none of the above
Term
Which of the following was probably the first genetic material on Earth?
Definition
RNA
Term
A rare recessive trait in a pedigree is indicated by which pattern of inheritance?
Definition
horizontal
Term
An individual can be a heterozygote for one trait and a homozygote for another.
Definition
True
Term
A ____ is done to determine the genotype of an individual with a dominant phenotype
Definition
testcross
Term
Which of the following ratios indicates a lethal gene?
Definition
2:1
Term
In epistasis, one genes alleles mask the effects of another genes alleles
Definition
True
Term
In complementary gene action, dominant alleles of two or more genes are required to generate a particular trait.
Definition
True
Term
The nonsex chromosomes are called autosomes.
Definition
True
Term
If yellow and round phenotypes in peas are dominant, you know the genotype of all peas are green and wrinkled.
Definition
True
Term
The symbol indicates:
0-[]
Definition
mating
Term
___ is fertilization when both egg and pollen come from the same plant
Definition
self-fertilization
Term
Multifactorial inheritance is when a phenotype arises as a result of multiple genes interacting with each other and/or the environment
Definition
True
Term
A YY or yy genotype is called heterozygous
Definition
False
Term
Dihybrind test crosses are made between each pairwise combination of the 3 genes O,P and Q with the following results, you wish to use the chi square test chi determine whether O and P are linked which set of data would you use?
Definition
First cross
Term
Which of the following events occur during mitosis but not during meiosis?
Definition
None of the above
Term
What happens physically during the process of crossing over?
Definition
Two homologues chromatids break and rejoin at precisely the same site along the chromosome so that there is no loss or gain of material on either product
Term
recombination due to crossing over occurs only rarely in mitosis? (T/F)
Definition
True
Term
Suppose a 3 point test cross was conducted involving the genes ABC if the most abundant classes are ABc and abC and the rarest classes are aBC and Abc, which gene is in the middle?
Definition
B
Term
The complementary sequence of 5AATTCGCTTA3 is
Definition
5TAAGCGAATT3
Term
The chromosomal structure to which spindle fibers attach during the mitotic division is referred to as a
Definition
Kinetochore
Term
If 25% of the bases in a region of the mouse genome are cytosine, what % in that region are adenine?
Definition
25%
Term
The period between cell cycles is called interphase
Definition
False
Term
Meselson and Stahl relied on equilibrium density gradient centrifugation in a _ solution to resolve the DNA containing N14 from N15
Definition
cesium chloride
Term
the measured distance between genes D and E in a two point test cross is 50 map units, what does this mean in physical terms?
Definition
Either D and E are on different pairs of chromosomes or D and E are linked at least 50 map units apart
Term
Two genes are considered linked when F2 progeny more commonly show the recombinant genotype
Definition
False
Term
How many replication forks depart from an origin of replication in eukaryotic cells?
Definition
Two
Term
Drosophila has four pairs of chromosomes. Sperm from thesis are formed by meiotic process in which homologous chromosome pair and segregate but do not undergo crossing over. How many genetically different kinds of sperm could be produced by drosophilia male?
Definition
16
Term
compared to SMOOTH streptococcus, ROUGH streptococcus has a mutation which makes it less virulent
Definition
true
Term
recombination events are limited to only "hot spots" along a chromosome
Definition
False
Term
At which of the following stages of meiosis would homologous chromosomes be paired?
Definition
both prophase and of meiosis 1 and metaphase or meiosis 1
Term
chiasmata can be seen through a light microscope and are sites of recombination
Definition
true
Term
Recombination involves the breakage and reunion of DNA molecular from
Definition
Homologous NONSISTER chromatids
Term
what radiolabeled substance did Hershey and Chase use to label the protein component of the bacteriophage in their study to determine whether protein or DNA was necessary for phage production
Definition
sulfur
Term
If one observes flower colors of white, pink and red, that would indicate codominant inheritance
Definition
False
Term
Duplications of the genes, followed by mutation, is responsible for the formation of _____
Definition
gene families
Term
To brush the pollen from one plant onto the female organ of another plant, thereby creating offspring with the particular traits of the selected plants is _____
Definition
cross-fertilization
Term
In a monohybrid cross between a homozygous dominant individual and a homozygous recessive individual (both P), what proportion of the homozygotes(or heterozygotes) is expected among the F2 offspring?
Definition
1/2
Term
The first offspring from the parents is/are called
Definition
F1
Term
Genes with more than one type of allele are termed polymorphic
Definition
True
Term
The phenotypic ratio 3:1 may indicate
Definition
complete dominance
Term
The phenomenon of a single gene determining a number of distinct and seemingly unrelated characteristics is known as pleiotropy
Definition
True
Term
DNA arrays/chips allows one to examine gene expression, whereas DNA sequencing does not allow one to examine gene expression
Definition
True
Term
If the parents of a family already have two boys, what is the probability that the next two offspring will be girls?
Definition
1/4
Term
Mendel's law of segregation states that two alleles for each trait unite in a specific manner during gamete formation and therefore give rise to predictable observable traits.
Definition
False
Term
An alternative form of a single gene is known as
Definition
an allele
Term
When a late blooming pea and an early blooming pea are crossed, an intermediate phenotype occurs. This results in blending
Definition
False
(incomplete dominance)
Term
The Bombay phenotype is an example of
Definition
recessive epistasis
Term
Mutations are a source of new alleles
Definition
True
Term
Crosses in which the male and female traits are reversed, thereby controlling whether a particular trait is transmitted by the egg or pollen are known as_____
Definition
reciprocal crosses
Term
An allele that expresses its phenotype even when heterozygous with a recessive allele is termed
Definition
dominant
Term
A phenotype reflecting a new combination of genes occurring during gamete formation is called
Definition
a recombinant type
Term
Which of the following ratios show incomplete dominance and codominance?
Definition
1:2:1
Term
In the Hershey and chase Blender experiment designed to determine the macromolecule of heredity, where was the majority of radioactive sulfur found?
Definition
in the supernatant
Term
Pyrimidine's are Nitrogenous base contain a double ring, while purines contain a dingle ring
Definition
False
Term
Viruses use only DNA as their genetic material
Definition
False
Term
chromosomal interference is not uniform and may significantly vary within a region of a single chromosome
Definition
True
Term
Which scientist determined nucleotide ratio in DNA?
Definition
Chargaff
Term
Red green color blindness is controlled by an X chromosomal gene in human. A normal man and a normal woman whose father are both color blind marry. What is the probability of their first child will be color blind?
Definition
1/4
Term
crossing over between homologous chromosomes occur at which of the following states of meiosis?
Definition
Prophase 1
Term
Crossing over between homologues chromosomes occurs at which of the following states of meiosis
Definition
Prophase 1
Term
humans have 22 pair of autosomes plus one sex chromosome pair. How many autosomes are present in a normal human primary spermatocyte?
Definition
44
Term
genes chained together by linkage relationships are known collectively as linkage groups
Definition
True
Term
chromosomes attach to microtubules through linkage groups
Definition
False
Term
what process of meiosis do we see Mendel's two laws played out?
Definition
1) Law of segregation: Anaphase 1

2) Law of Independent assortment: Meta phase 1
Term
In complementary gene action, recessive alleles of two or more genes are required to generate a particular trait
Definition
False
Term
In a monohybrid cross between parents Aa x Aa, (both P) what proportion of heterozygotes is expected among the F1 offspring?
Definition
1/2
Term
Which of the following lines produce offspring that carry a specific parental traits that remain constant from generation to generation?
Definition
pure-breeding
Term
The second generation of offspring from the parents are called
Definition
F2
Term
During gamete formation, different pairs of alleles on different chromosomes segregate independently of each other
Definition
True
Term
In the dihybrid cross AABB x aabb (both P generation), what proportion of heterozygotes for both gene pairs is expected among the F2 offspring?
Definition
1/4
Term
The actual alleles present in an individual make up the individual's
Definition
genotype
Term
The punnett square was introduced by a geneticist named punnett and provide a simple and convenient method of tracking possible combination of gametes that might be produced in a given cross
Definition
True
Term
A rare dominant trait in a pedigree is indicated by which pattern of inheritance?
Definition
vertical
Term
In incomplete dominance, F1 hybrids show the traits of both parents
Definition
False
Term
A person who has type O blood has
Definition
both anti-A and anti-B antibodies
Term
On a pedigree chart, a colored square indicates a ____.
Definition
male with the disorder being studied
Term
A Yy genotype is called heterozygous
Definition
True
Term
During gamete formation, different pairs of alleles on different chromosomes assort independently of each other
Definition
True
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