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Genetics Exam 1
Genetics Exam 1 CSU
78
Biology
Undergraduate 3
02/18/2013

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Term
Genes
Definition
basic unit of biological information, factor that controls a trait, specific segment of DNA in a discrete region of a chromosome that serves as a unit of function by encoding a particular RNA or protein
Term
Inheritance
Definition
passage of characteristics from parents to offspring
Term
Domains
Definition
Archaea, Bacteria, Eukarya
Term
Archaea
Definition
extremophiles, prokaryotes, unicellular, asexual
Term
Bacteria
Definition
metabolic diversity, unicellular, asexual
Term
Eukarya
Definition
Plants, animals, fungi, protists; multicellular and known for complexity, sexual reproduction
Term
Central Dogma of Biology
Definition
DNA -------> RNA ---------> Proteins
(transcription) (translation)
Francis Crick
Term
Mendel's First Law of Segregation
Definition
two alleles for each trait separate during gamete formation and then unite at random, one from each parent at fertilization
Term
Test Cross
Definition
a cross used to determine the genotype of an individual showing a dominant phenotype by mating with an individual showing recessive phenotype, crossing F2 with a recessive homozygote
Term
Null hypothesis
Definition
a statistical hypothesis to be tested and either accepted or rejected in favor of an alternative
Term
Backcross
Definition
F1 progeny crossed with one of the parents, labradoodle, backcrossing to get more characteristics of one parent
Term
Allele
Definition
different forms of a factor
Term
True-breeding
Definition
homozygotes
Term
Self-fertilization
Definition
selfing, fertilization in which both egg and pollen come from the same plant
Term
Reciprocal cross
Definition
crosses in which the traits in the males and females are reversed, thereby controlling whether a particular trait is transmitted by the egg or pollen
Term
Progeny Testing
Definition
selfing the F2
Term
Gametes
Definition
specialized haploid cells that carry genes between generations, eggs or sperm
Term
Heterozygote advantage
Definition
heterozygotes are more vigorous
Term
Mendel's 2nd Law of Independent Assortment
Definition
the random distribution of different genes during gamete formation, different pairs of alleles segregate independently of each other
Term
Stochastic events
Definition
a state you can't determine, determined by the system's predictable actions and by random element
Term
Sum rule
Definition
the probability that any of two or more mutually exclusive events will occur is the sum of their individual probabilities
Term
Product Rule
Definition
states that the probability of two or more independent events occurring together is the product of the probabilities that each event will occur by itself
Term
Multinomial theorem
Definition
P = n!p^sq^tr^u …
s!t!u! …
Term
Proband
Definition
an individual affected with a disorder who is the first subject in a study
Term
Consanguineous mating
Definition
close mating, like first cousins
Term
Codominant
Definition
expression of heterozygous genotype resulting in hybrid offspring that resemble both parents equally for a particular trait
Term
Polymorphic gene
Definition
a locus with two or more distinct alleles in a population
Term
Dominance series
Definition
dominance relations of all possible pairs of alleles are arranged in order from most dominant to most recessive
Term
Digenic
Definition
inheritance of alleles at 2 different genes
Term
Epistasis
Definition
a gene interaction in which the effects of an allele at one gene hide the effects of alleles at another gene
Term
Dominant epistasis
Definition
the effects of a dominant allele at one gene hide the effects of alleles at another gene
Term
Recessive epistasis
Definition
special case of epistasis in which the allele causing the epistasis is recessive
Term
Epistatic gene
Definition
describes an allele of one gene that masks the effects of one or more allele of another gene
Term
Hypostatic gene
Definition
the phenotype is masked by the expression of an allele at a separate locus, epistatic event, masked by an epistatic gene
Term
Complementation
Definition
process in which heterozygosity for chromosomes bearing mutant recessive alleles for two different genes produces a normal phenotype
Term
Dominant lethal
Definition
kill organism in homozygous and heterozygous state, most dead before born
Term
Recessive lethal
Definition
kill organism in homozygous state, heterozygotes are carriers
Term
Incomplete dominant lethal
Definition
homozygotes recessive are lethal, homozygotes dominants are normal, and heterozygotes look different
Term
Carriers
Definition
heterozygous individuals of normal phenotype that have a recessive allele for a trait
Term
Pleiotrophy
Definition
phenomenon in which a single gene determines a number of distinct and seemingly unrelated characteristics
Term
Reduced penetrance
Definition
less than 100% of people with a given genotype show the phenotype
Term
Variable expressivity
Definition
how intense the phenotype is expressed, different levels in individuals with the same genotype
Term
Modifier genes
Definition
genes that produce a subtle, secondary effect on phenotype
Term
Nucleus
Definition
Eukaryotic structure, nuclear membrane surrounds,contains DNA
Term
Chromosome
Definition
multiple, linear DNA, genome
Term
Chromatid
Definition
one of two copies of a chromosome that exist immediately after DNA replication
Term
Relaxed and Condensed Chromosome
Definition
Term
Histones
Definition
small DNA binding proteins, fundamental protein components of nucleosomes, basic-positively charged
Term
Nucleosome
Definition
rudimentary DNA packaging unit; composed of DNA wrapped around a histone protein core
Term
30nm Fiber
Definition
Term
Scaffold Associated Regions
Definition
SARs special, irregulary spaced repetitive base sequences of DNA that associate with nonhistone proteins to define chromatin loops. Most likely the sites at which DNA is anchored to the condensation scaffold
Term
Chromonema
Definition
Term
Chromatin
Definition
generic term for any complex of DNA and protein found in a cell's nucleus
Term
Sister chromatids
Definition
two identical copies of a chromosome that exist immediately after DNA replication, held together by cohesins
Term
Centromere
Definition
specialized chromosome region at which sister chromatids are connected and to which spindle fibers attach during cell division
Term
Kinetochore
Definition
specialized chromosomal structure composed of DNA and proteins that is the site at which chromosomes attach to the spindle fibers
Term
NOR
Definition
nuclear organizing region-2nd constriction site, site of rRNA synthesis, nucleolus
Term
Telomeres
Definition
specialized terminal structures on eukaryotic chromosomes that ensure the maintenance and accurate replication of the two ends of each linear chromosome
Term
Genome
Definition
Term
Constant amount of DNA in one genome- 1c
Definition
Term
Homologous chromosomes or homologs
Definition
Term
Karyotype and ideogram
Definition
Term
Sex determination by environment
Definition
Term
Sex determination by ploidy
Definition
Term
Sex determination by Sex locus
Definition
Term
Sex determination by Sex chromosomes
Definition
Term
Autosomes
Definition
Term
Homomorphic, homogametic, heteromorphic, heterogametic
Definition
Term
Pseudoautosomal regions
Definition
Term
Eukaryotic cell cycle
Definition
Term
Interphase, G1, S, G2, G0
Definition
Term
Cytokinesis
Definition
Term
Cohesis
Definition
Term
Centrosomes
Definition
Term
Mitosis, Prophase, Prometaphase, Metaphase, Anaphase, Telophase
Definition
Term
Expected # of phenotypes
Definition
2^n
2^1= 2 phenotypes
2^2= 4 phenotypes
Term
Expected # of gametes in F1
Definition
2^n
monohybrid cross: 2^1=2 gametes-> 2*2= 4
dihybrid cross: 2^2= 4 gametes -> 4*4= 16 progeny
Term
Expected # of genotypes
Definition
3^n
monohybrid: 3^1=3
dihybrid: 3^2= 9 genotypes
tetrahybrid: 3^3=27 genotypes
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