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Genetics condensed
Genetics condensed
48
Biology
Undergraduate 1
08/12/2010

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Term
Mendel's 4 principles of inheritance
Definition
-genes exist in alternate forms
-an organism has 2 alternate forms for each trait, one from each parent
-two forms segregate during meiosis
-if two forms are different, one is dominant
Term
Mendel's first law
Definition
-segregation
-when an individual produces gametes, the two copies of a gene seperate, so each receives only one copy
Term
Mendel's second law
Definition
-independent assortment
-alleles of different genes assort independently during gamete formation
Term
incomplete dominance
Definition
when heterozygote expresses both parental genes BLENDED
Term
codominance
Definition
when heterozygte expresses both parental genes UNBLENDED
Term
men pass X chromosomes to only to
Definition
daughters
Term
sex linked recessives generally only affect
Definition
men
Term
environment can often affect
Definition
expresion of a gene
Term
DNA
Definition
deoxyribose (sugar) bonded to phosphate and nitrogenous base
Term
purines
Definition
A G
Term
pyrimidines
Definition
C T
Term
degeneracy
Definition
many codons code for same amino acid
Term
RNA
Definition
uracil and usually single stranded
Term
most abundant RNA
Definition
rRNA
Term
transcription occurs in
Definition
nucleus
Term
translation occurs in
Definition
cytoplasm
Term
order of ribosome sites
Definition
EPA
Term
P site
Definition
holds tRNA carrying growing polypeptide
Term
A site
Definition
holds tRNA holding next amino acid
Term
E site
Definition
exit site
Term
nondisjunction
Definition
chromosomes fail to seperate
Term
chromosomal breakage
Definition
may occur spontaneously or be induced by environment
Term
point mutation
Definition
single base subtitution
Term
missense
Definition
code for different amino acid
Term
nonsense
Definition
code for STOP codon
Term
bacterial genome
Definition
ds circular DNA, plasmids, episomes
Term
plasmids
Definition
code for accessory genes
Term
episomes
Definition
plasmids capable of integration into bacterial genome
Term
bacterial replication
Definition
-proceeds in both directions simultaneously
Term
bacterial transcription/translation
Definition
-translation can occur before transcription is finished
Term
tranformation
Definition
foreign chromosome (plasmid) is integrated into bacterial chromosome
Term
conjugation
Definition
transfer of genetic material between two temporarily linked bacteria
-must contain plasmids called sex factors
Term
regulation of gene expression allows for control of
Definition
metabolism
Term
sructural genes
Definition
code for proteins
Term
operator genes
Definition
noncoding, repressor binding site
Term
promotor genes
Definition
noncoding, RNA polymerase binding site
Term
regulator genes
Definition
code for repressor
Term
inducible system
Definition
usually off, can be turned on
Term
repressible system
Definition
usually on, can be turned off
Term
lethal dominant genes are less common because
Definition
they kill homozygous dominant and heterozygous thus lowering the frequency in the gene pool
Term
DNA replication
Definition
-helicase unwinds
-primase make RNA primer
-DNA polymerase synthesizes 5' to 3'
-DNA polyerase replaces RNA primer with DNA
Term
helicase
Definition
unwinds DNA in DNA replication
Term
primase
Definition
makes RNA primer in DNA replication
Term
liagase
Definition
joins Okazaki fragments
Term
Transcription
Definition
-RNA polymerase binds to promotor and unwinds DNA
-RNA pairs with one complementary strand
Term
leading/lagging stand occur
Definition
simultaneously
Term
RNA processing
Definition
-5' Cap and Poly-A tail added
-sNRPs (spliceosomes) cut out introns and splice exons
Term
Translation
Definition
-small ribosomal subunit attaches to mRNA
-anticodon binds to start codon
-large ribosomal subunit attaches
-initiation, elongation, termination
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