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Father of Modern Genetics. Worked with pea plants. Discovered Law of Segregations and Independent Assortment. |
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Discovered role of Chromosomes in inheritance. Worked with Drosophila. Nobel Prize, 1933. |
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Discovered that "factors" from dead bacteria could be inserted into live bacteria, AKA Transformation. |
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Developed Complementation Test. |
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Discovered that DNA was present in chromosomes, and that RNA was present in all cells. |
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Edward Lawrie Tatum and George Wells Beadle |
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Showed that genes code for proteins, and that one gene codes for one specific enzyme. |
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Avery, MacLoed, and McCarty |
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Showed that DNA was the genetic material, then known as the 'transforming principle'. |
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Showed the A + G was roughly equal to T + C. |
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Discovered Transposons in maize. |
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Proved that the genetic information of phages (and by extension most all other organisms) was DNA. |
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James D. Watson and Francis Crick |
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Discovered the Structure of DNA. |
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Discovered that DNA replication was semiconservative. |
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Marshall Nirenberg, Har Gobind Khorana, Sydney Brenner & Francis Crick (Crick, Barnett, Brenner, Watts-Tobin 1961) |
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"Cracked" the genetic code, i.e. which base sequences coded for which amino acids, and that the code was |
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X-ray Crystallographer, whose images of DNA assisted Watson and Crick in determining it's structure. |
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Mapped the gene sequence of bacteriophage MS2-RNA. |
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Fred Sanger, Walter Gilbert, and Allan Maxam |
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Sequenced DNA, working independently. |
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Mapped the gene sequence of bacteriophage Φ-X174, as well as doing some protein mapping. |
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Francis Collins and Lap-Chee Tsui |
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Mapped the CSFR gene, which when defective causes cystic fibrosis. |
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Discovered cause of sickle-cell anemia: HbS, a defective hemoglobin protein. |
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Discovered that DNA -> Protein was colinear. |
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Developed fine structure mapping of bacteriophage. |
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Discovered galactose system in bacteria. |
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Discovered Replication Fork in DNA. |
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Aside from wooing several ladies in the visual novel Clannad... oh wait, wrong Okazaki. Discovered fragments in the discontinuous 3' -> 5' synthesis pattern. |
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Discoverd Hybrid Dysgenesis. |
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U-tube experiment, which proved that contact was necessary for Conjugation to occur. |
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Harriet Creighton and Barbara McClintock |
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Showed that crossing over was the method of recombination of linked genes. |
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Crossed a cabbage with a radish in 1928. Tragically, the hybrid had the head of a radish and the root of a cabbage. |
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Joshua Lederberg and Edward Tatum |
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Elie Wollman and Francois Jacob |
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Joshua Lederberg and Norton Zinder |
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