Term
What is the likelihood of having a child with an autosomal recessive trait |
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Definition
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Term
Name 3 substances that people with the CYP2D6 polymorphism metabolise differently to people without that polymorphism |
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Definition
Debrisquone Haliperidol Cardiovascular drugs |
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Term
Are people with CYP2D6 polymorphism slow metabolisers of debrisquone. |
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Definition
Yes. They can suffer hypotension due to high drug concentration. |
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Term
What side effects can people with CYP2D6 polymorphism suffer when taking anti-psychotics |
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Definition
Parkinsons like due to high drug concentration as they are poor metabolisers of these drugs |
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Term
What opioid pro-drug is metabolised by CYP2D6 |
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Definition
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Term
Do polymorphisms exist in alcohol dehydrogenase |
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Definition
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Term
Name the polymorphism that is associated with sulfonamide toxicities |
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Definition
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Term
How is sulphonamide toxicity manifested? |
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Definition
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Term
How might a slow acetylator be affected if given isoniazid |
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Definition
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Term
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Definition
colon, liver, small intestine |
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Term
Name the cells which rely totally on G6PDH for protection from reactive oxygen species |
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Definition
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Term
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Definition
It produces reduced co-factor which is a source of reducing equivalents for glutathione reductase |
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Term
Name the enzyme involved in reduction of ROS |
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Definition
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Term
Name drugs that can cause haemolytic anaemia in G6PDH deficiency |
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Definition
antimalarials, sulphonamides, non-sulfa antibiotics |
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Term
What is the cause of pro-longed paralysis (hours) in some patients |
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Definition
Atypical plasma cholinesterase |
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Term
What does TPMT stand for? |
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Definition
Thiopurine Methyltransferase |
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Term
What is the effect of reduced TPMT ? |
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Definition
High levels of 6-thioguanine nucleotides which halt cell proliferation and can suppress bone marrow causing low WBC count |
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