Shared Flashcard Set

Details

Genetic Polymorphisms
Dr. van Pelt UCC
17
Pharmacology
Undergraduate 2
10/23/2017

Additional Pharmacology Flashcards

 


 

Cards

Term
What is the likelihood of having a child with an autosomal recessive trait
Definition
25%
Term
Name 3 substances that people with the CYP2D6 polymorphism metabolise differently to people without that polymorphism
Definition
Debrisquone
Haliperidol
Cardiovascular drugs
Term
Are people with CYP2D6 polymorphism slow metabolisers of debrisquone.
Definition
Yes. They can suffer hypotension due to high drug concentration.
Term
What side effects can people with CYP2D6 polymorphism suffer when taking anti-psychotics
Definition
Parkinsons like due to high drug concentration as they are poor metabolisers of these drugs
Term
What opioid pro-drug is metabolised by CYP2D6
Definition
Codeine
Term
Do polymorphisms exist in alcohol dehydrogenase
Definition
Yes
Term
Name the polymorphism that is associated with sulfonamide toxicities
Definition
Acetylation polymorphism
Term
How is sulphonamide toxicity manifested?
Definition
Haemolytic anaemia
Term
How might a slow acetylator be affected if given isoniazid
Definition
peripheral nerve damage
Term
Where is NAT-2?
Definition
colon, liver, small intestine
Term
Name the cells which rely totally on G6PDH for protection from reactive oxygen species
Definition
Red Blood Cells
Term
Why is G6PDH important
Definition
It produces reduced co-factor which is a source of reducing equivalents for glutathione reductase
Term
Name the enzyme involved in reduction of ROS
Definition
Glutathione peroxidase
Term
Name drugs that can cause haemolytic anaemia in G6PDH deficiency
Definition
antimalarials, sulphonamides, non-sulfa antibiotics
Term
What is the cause of pro-longed paralysis (hours) in some patients
Definition
Atypical plasma cholinesterase
Term
What does TPMT stand for?
Definition
Thiopurine Methyltransferase
Term
What is the effect of reduced TPMT ?
Definition
High levels of 6-thioguanine nucleotides which halt cell proliferation and can suppress bone marrow causing low WBC count
Supporting users have an ad free experience!