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Definition
| a mutation that is not induced by a mutagenic agent |
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Definition
| mutations that result from the influence of extraneous factors |
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Term
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Definition
| gametes receive aberrant chromosomes and fail to develop normally, if at all; germ-line mutations |
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Definition
| a nonheritable mutational event occurring in a somatic cell |
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Definition
| when a mutation interrupts a process that is essential to the survival of the organisms |
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Definition
| a mutation that expresses a wild-type phenotype under certain (permissive) conditions and a mutant phenotype under other (restrictive) conditions |
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Definition
| greater activity or more visible trait |
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Definition
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Term
| loss of function mutation |
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Definition
| a mutation that eliminates the function of the gene product |
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Term
| gain of function mutation |
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Definition
| results in a gene product with a new function |
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Term
| dominant negative mutation |
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Definition
| bad apple spoils the bunch e.g. bad protein in multicomponent enzyme |
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Term
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Definition
| a mutation that can be mapped to a single locus. at the molecular level, a mutation that results in the substitution of one nucleotide for another |
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Term
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Definition
| a mutational event leading to the insertion of one or more base pairs in a gene, shifting the codon reading frame in all codons that follows the mutational site |
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Term
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Definition
| a mutational event in which one purine is replaced by another of on pyrimidine is replaced by another |
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Term
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Definition
| a mutational event in which a purine is replaced by a pyrimidine or a pyrimidine is replaced by a purine |
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Term
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Definition
| if the point mutation alters a codon but does not interfere with the amino acid at the position in the protein (due to degeneracy of the genetic code) |
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Term
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Definition
| a mutation that alters a codon to that of another amino acid, causing an altered translation product to be made |
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Term
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Definition
| a mutation that changes an amino acid codon into a termination codon: UAG, UAA, or UGA. leads to premature termination during translation of mRNA |
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Term
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Definition
| transposons are often inserted into a gene, disrupting the normal coding sequence; may be agents of spontaneous mutations |
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