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Genetic Disease Analysis
Biology 200 Lecture Notes
8
Biology
Undergraduate 2
08/16/2011

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Term
What is Freeman's definition of the allele?
Definition
- A particular version of a gene.
- The "r" and "R" versions of a gene are alleles.
- The wild-type and mutant versions of a gene are also alleles.
Term
What is the class definition of the allele?
Definition
- A particular version of a region of DNA.
- Can be a non-coding allele.
- Differences in alleles can be as little as a single base pair or as large as an insertion/deletion of many thousands of bases.
Term
How do you test for hereditary disease?
Definition
1) Find a huge population.
2) Find obvious mutants.
3) Do specific test crosses and compare the results with your expectations.
Term
When test crossing is difficult, use..
Definition
a pedigree.
Term
What can inbreeding lead to?
Definition
Increase likelihood of homozygous recessives or X-linked trait expression.
Term
What is genetic mapping?
Definition
Make a representation of all chromosomes and the locations of all known genes.
Term
Crossing Over in Meiosis
Definition
- Crossing over is rare between genes that are close together.
- Crossing over occurs frequently between genes that are far apart.
Term
Mapping Genetic Distance
Definition
Frequency of recombinant offspring correlates directly with the distance between two genes.
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