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found on T cells, bind MHC class 2
CD4+ T cells regulate other T cells, B cells, Macrophages, NK cells |
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| found on T cells, bind MHC class 1 |
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| secreted by Th1 cells, recruit more T cells, key in delayed type hypersensitivity |
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secreted by TH1 cells
major macrophage activating factor |
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| secreted by Th2 cells, turns on IgE-producing B cells, responsible for hypersensitivity type 1 |
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| secreted by TH2 cells and mast cells, activates eosinophils MOST POTENT! |
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| secreted by TH2 cells, promotes IgE production and mucus secretion |
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| expressed on B cells, bind CD40 ligand for B cell activation |
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| Expressed on T cells, activate CD40 that is expressed on B cells and enable them to mature |
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| Fc receptor for IgG, expressed on NK cells for ADCC |
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| stimulatory protein expressed by virally infected or tumor cells and recognized by NK cells |
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| secreted by TH2 cells and mast cells, activates eosinophils |
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| produced by macrophages and critical for inducing the TH1 response, seen in delayed type hypersensitivity |
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| located on T cells, co-stimulation requirement for activation based on ligand on APCs |
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| on regulatory T cells (CD4+) that prevent immune reactions against self-antigens |
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| responsible for the proliferation of lymphoid progenitors (especially T cell precursors) |
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PRIMARY MEDIATOR
smooth muscle contraction, increased vascular permeability, increased nasa, bronchial, and gastric secretion |
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| most potent vasoactive and spasmogenic agents known |
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| highly chemotactic for neutrophils, monocytes, and eosinophils |
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