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rapid induction & recovery (low solub in blood & tissues) elim in lungs; no metabolism low potency anesthetic; effective analgesic interaxn w/ B12 in enteric bac --> B12 deficiency
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slow induction & recovery elim by lungs (80%) & liver malignant hyperthermia hepatotoxicity in adults - OK for kids preg. women - can prolong labor (inhib uterine contractions) decr BP (cardiac depression) cerebral vasodilator --> incr ICP
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slow induction & recovery used for maintenance anesthesia decr. BP; minimal effects on HR cerebral vasodilation --> incr ICP skel mm relaxn seizures
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not metabolized; excr'd by lungs decr BP (decr vasc resist; CO maintained) coronary vasodilator incr. cerebral blood flow; transient incr. CSF pressure malignant hyperthermia
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rapid induction and recovery decr. BP; cardiac depressant bronchodilation seizures malignant hyperthermia rare post-surg hepatic dysfxn (+/- jaundice)
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barbituate (IV) rapid action, short duration; "induction" lipid solub; crosses BBB, accumulates in adipose respiratory & cardiac depression narrow therapeutic margin not analgesic contraindicated: cardiovasc disease, Addison's, hepatic/renal dysfxn, myxedema, hi blood urea, anemia, myasthenia gravis
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imidazole (IV) - like thiopental but rapid metab no cardiovasc or resp depression involuntary mvmts during induction decr ICP; decr IOP reduced plasma cortisol; lasts 6-8 hrs, resist to ACTH
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IV - "dissociative anesthesia" PCP analog; may cause psychosis neuroprotective in ischemic brain injury & glutamate-induced injury incr. BP & HR
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