Term
| Gastric acid is secreted by _______ cells |
|
Definition
|
|
Term
| the proton pump is also called ______ |
|
Definition
|
|
Term
| adverse effects of H2-receptor antagonists |
|
Definition
| diarrhoea, dizziness and muscle pain |
|
|
Term
| How does cimetidine differ from other H2-receptor antagonists |
|
Definition
| it is an inhibitor of CYP-450 |
|
|
Term
| what are the four classes of drugs used in PUD and GORD |
|
Definition
antacids
H2 receptor antagonists
proton pump inhibitors
muscarinic antagonists |
|
|
Term
| are proton pump inhibitors reversibly or irreversibly bound to enzyme |
|
Definition
|
|
Term
| side effects of long term use of PPI's |
|
Definition
| hypochlorhydria and hypergastremia, which has lead to increase gastric tumours in animals |
|
|
Term
| class and activity of Pirenzipine |
|
Definition
| pirenzipine is a M1 receptor blocker, reduces secretion of gastric acids |
|
|
Term
| what are the common side effects of Pirenzipine |
|
Definition
| dry mouth and blurred vision |
|
|
Term
|
Definition
act by neutralizing acid and slightly increasing gastric pHrapid pain relief
|
|
|
Term
| adverse effect of magnesium hydroxide and magnesium trisilicate |
|
Definition
|
|
Term
| adverse effect of aluminium hydroxide gel |
|
Definition
|
|
Term
| side effects of Calcium carbonate and Sodium bicarbonate |
|
Definition
generation of CO
2 (belching)
+
possible systemic side effects (metabolic alkalosis)
|
|
|
Term
| drugs for the protection of gastric mucosa |
|
Definition
| bismuth chelate, misoprostal, sucralfate |
|
|
Term
| key features of bismuth chelate |
|
Definition
–eradicating H.pylori in 30% of patients
–coating the ulcer base
–adsorbing pepsin and local PG synthesis
|
|
|
Term
| key features of misoprostal in GI |
|
Definition
–inhibits gastric acid secretion
–maintains or increases mucosal blood flow
–increases the secretion of mucus and bicarbonate
|
|
|
Term
| the two commonly used therapy for H.pylori erradication |
|
Definition
Triple Therapy: PPI+ Clarithromycin + amoxicillin/metronidazole
Quadruple Therapy: PPI + Bismuth + amoxicillin/metronidazole + tetracycline
|
|
|
Term
| class and ADR of hyoscine |
|
Definition
anticholinergic
anticholinergic SE + sedation |
|
|
