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Fungal Infections
Medical Microbiology - Mycology Diseases
22
Microbiology
Undergraduate 2
02/12/2011

Additional Microbiology Flashcards

 


 

Cards

Term
[image]Penumocystosis
Definition

Opportunistic - Pneumocystis Carinii

world wide
respiratory infection (pneumonitis c plasma cells)
AIDS, hosptialized, old, immunosuppressed
d(x): sputum ,lavage, biopsy, stain , flourescent antibody

t(x):  trimethoprim
, pentamidine (aerosol)

Term
Candidiasis
Definition

Opportunistic - Candidia albicans

white patches
chronic mucocutaneous: in skin
disseminated: gut, renal, pulmonary

t(x): oral: nystatin, amphotericin B, gentian violet
t(x): enteritis: ketoconazole
t(x): vaginitis: nystati/amphotericin B
t(x): systemic: amphotericin B & 5-fluorocytosine

Term
Aspergillosis
Definition

Opportunistic - Aspergillus

granulomatous lesions
secondary to other chronic disesases
mycotoxicoses: food
hypersentivity
secondary colonization
systemic mycoses: organs
hard to isolate; branching septate hyphae

Term
Zygomycosis
Mucormycosis
Phycomycosis
Definition
Opportunistic
Term
Black piedra
Definition

Superficial - piedraia hortai
small black nodule on hair

t(x): cut hair, fungicidal shampoo

Term
White piedra
Definition

Superficial - trichasporon begelii
soft beige nodule (distal end of hair shaft)

t(x): cut hair, fungicidal shampoo

Term
Pityriasis Versicolor
Definition
Superficial - malassezia furfur
grow in superficial keratin
hypo/hyperpigmentation (back, neck, chest, shoulders)
can see hyphae and spores
Term
Tinea nigra
Definition
Superficial - phaeoannellomyces werneckii
silver-nitrate like stain (palms)
Term
Epidermophyton
Definition

Cutaneous - Dermatophytoses

branching septate hyphae; look like baseball bats

Term
Microsporum
Definition

Cutaneous - Dermatophytoses

septate hyphae (see nuclei); leaf/canoe shape 8 spores

ringworm

extothrix: lie on outside of hair shaft; seen with UV light M. audouinii: in temperate climate ; contagious; spread by barber tool/head contact

M. canis: 2nd most common, spread by young animals

Term
Trichophyton
Definition

Cutaneous - Dermatophytoses

grow on thicker skin (ie: pads of feet, nailbed); dry & scaly, last 10+years; see spores, hyphae, septate; giveaway is location, external spores, and many colours

Term
Tinea infections
Definition

Cutaneous

- capitus - head, itchy, hair breaks off, contagious

- barba - face

- corporis - body, advancing circles, hair loss, poor nutrition/hygiene associated

- cruri - groin, epidermophyton floccosum/inguinale or trychophyton, after abrasion occurs

- pedia - feet, “athlete’s foot”, between toes, desquamation, inflammation, painful epidermophyton or trychophyton
       

- unguium - nails, thick brittle & discoloured, trichophyton rubrum (women 40-45), hard to treat

Term
Dermatomycoses
Definition

Cutaneous

deeper and more invasive than phytoses; inflammation

caused by opportunistic fungi

t(x): topical sulfur+salicylic acid, crystal violet, iodine, tolnaftate, undecylenic acid, miconazole, haloprogin,     griseofulvin (1g/day 1-3 months)

Term
Dermatophytoses
Definition

Cutaneous

t(x): topical sulfur+salicylic acid, crystal violet, iodine, tolnaftate, undecylenic acid, miconazole, haloprogin, griseofulvin (1g/day 1-3 months)

Term
Chromoblastomycosis
Definition

Subcutaneous

verrucoid (wart) skin lesions (lower extremties)
muriform cells (2-direction cross walls)
does not affect muscles, bone, or tendon

Term
Phaeohypomycosis
Definition

Subcutaneous

hyphal or yeast form, long-chain hyphae
dermatiaecous fungi - melanin black fungi

Term
Mycetoma
Definition

Subcutaneous

granulomatous local lesions (on feet/legs); madura foot
visible pigmentation (yellow); hyphal OR yeast
destroys bone, muscle, and tendon
Fungal -> Pseudallescheria boydii

Bacterial -> Nocardia Brailiensis

Term

Sporotrichosis

Definition

Subcutaneous

Spotothrix Schenkii - common in wood/soil; yeast in tissues; grows on agar like an island
- ulcerative lesions at site on skin, spreads to lymph nodes, highly infectious
uncommon in North America; introduced by thorns & moss; found in Mississippi/Missouri
t(x): topical potassium iodine or amphotericin B

Term
Histoplasmosis
Definition

Systemic

primary pathogen c capsule

may mimic TB; often in lungs; aka Spelunkers disease
may coexist with other bacteria or fungi
yeast form (dimorphic)
causes Ohio/Mississippi Valley Fever; found in soil with bat/bird droppings

problem for vetrinarians

Term
Coccidiomycosis
Definition

Systemic

primary pathogen
hyphal, capsules, spores but can see yeast; dimorphic; often in lungs; mimic TB; make sphirules
causes San Joaquin fever; lives in soil
lesion looks like non-dried cold sore
resp infection that may disseminate to meninges, bones, joins, subq and cut. tissues
t(x): bed rest, steroids, amphotericin B

Term
Blastomycosis
Definition

Systemic

primary pathogen
yeast form; dimorphic
rare (less infective)
cause Manitoba/St.Lawrence River Valley Fever
causes chronic pneumonia; granulomatous lesion, inflammation in lungs
dissemination to skin, bone, prostate
t(x); Amphotericin B

Term
Cryptomycosis
Definition

Systemic

opportunistic pathogen
tolerated by birds but not infectious to them; associated with pigeon droppings
capsules crossing BBB set up for meningitis (starts in lung); not from ingestion
eventually fatal is chronic; t(x) with amphotericin B
yeast form; makes a smooth mocoid-looking texture because cells can’t get close

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