Term
| What are the 3 groups of anti-inflammatory medications |
|
Definition
nonsteroidals
steroids
biologics (targeted medications) |
|
|
Term
| Which NSAID blocks platelet formation irreversibly? |
|
Definition
|
|
Term
| What syndrome occurs when you give children under 12 aspirin? |
|
Definition
| Reye syndrome (can cause ringing in your ears) |
|
|
Term
| What are the major groups of NSAIDS? |
|
Definition
salicylates
proprionic acid
oxicams
acetic acid
pyrazole |
|
|
Term
| What propionic acid NSAID causes pseudoporphyria in fair skinned people? |
|
Definition
| Naproxen (aleve)-COX 1 and 2 inhibitor |
|
|
Term
| Is aspirin or ibuprofen safer in terms of platelets? |
|
Definition
| ibuprofen is safer because it blocks platelet aggregation REVERSIBLY |
|
|
Term
Oxaprozin or Ketoprofen:
Which proprionic acid NSAID is more toxic than effective? Which one is sometimes used for joint pain and taken daily? |
|
Definition
|
|
Term
Of the oxicam NSAIDS (meloxicam, piroxicam, and nabumetone), which one causes GI bleeding?
How often are these drugs taken? |
|
Definition
|
|
Term
| *Which acetic acid NSAID is very strong, can used to treat Still's disease, arthritis, and inflammation but causes GI bleeding |
|
Definition
|
|
Term
| What is pyrazole NSAID that is a COX-2 inhibitor that down regulates prostaglandins in the endothelium, people got more heart attacks and clots, and good to use only if person does not have a heart condition? |
|
Definition
|
|
Term
What would you use for the following (codeine, naproxen, ibuprofen, morphine or ketorolac tromethamine/toradol)?
Pain, but not undergoing surgery
Pain and undergoing surgery
A lot of pain |
|
Definition
ibuprofen (rake 2, taking more won't give more pain control but will make it last longer) - ibuprofen gives better pain control than codeine
naproxen
toradol (gives equal pain relief as morphin and stronger through an IV)- don't use toradol more than 3 consecutive days |
|
|
Term
What drugs should you NOT give to a patient undergoing surgery?
What drug should you NOT give a patient with asthma and nasal polyps? |
|
Definition
ibuprofen and aspirin (can give naproxen instead)
aspirin (can increase asthma) |
|
|
Term
| What are the different types of steroids? |
|
Definition
Mineralocorticoids (blood pressure)
glucocorticoids (stress)
androgens and estrogens |
|
|
Term
| What happens when people take steroids for a long time? (ex: lupus patients) |
|
Definition
| they get infections easier, they cannot fight them |
|
|
Term
| What are the 2 places that steroids act? |
|
Definition
they block inflammation (block lipids going to arachidonic acid)
they get into the nucleus of the cell to block transcription/translation of certain genetic material
(makes it longer to heal because blockin collagen synthesis) |
|
|
Term
| What drug is the standard when comparing relative doses and equivalent potencies of glucocorticoids? |
|
Definition
| hydrocortisone (more mineralocorticoid-will affect Na/K pressure channel) |
|
|
Term
What are the 3 intermediate glucocorticoids?
What is their approx hydrocortisone dose, relative anti-inflammatory potency and relative sodium retain potency? |
|
Definition
Prednisone
prednisolone
methylprednisolone
hydrocortisone dose (4-5)
relative anti-inflammatory potency (4-5)
relative sodium retain potency (0.5-0.8) |
|
|
Term
| In uveitis, what type of drops should you use? |
|
Definition
steroid drops
(use antibiotics before) |
|
|
Term
What may you see in the mouths of patients who inhale steroid for asthma?
Patients who use steroid drops in their eyes? |
|
Definition
thrush
cataracts
(steroids can also restrict growth and cause edema, acne) |
|
|
Term
| What syndrome is it when patients taking steroids get hypertension, become fatter, moon face, buffalo hump, stretch marks? |
|
Definition
|
|
Term
| What happens when a patient (ex:lupus) decides to completely not take their steroids? |
|
Definition
| Taking steroids suppresses your own steroid production (hypothalamus and anterior pituitary) so you don't have adrenal production which can cause infection and become very sick |
|
|
Term
| What are the important cytokines for inflammation? |
|
Definition
|
|
Term
| Which cytokine is block in anti-inflammatory medication that is used mostly in systemic inflammatory conditions. |
|
Definition
|
|
Term
| Which cytokine is blocked in arthritis, some of the vasculitis but mostly arthritis |
|
Definition
|
|
Term
| what drug is used for arthritis but can cause granulomatous uveitis because it picks up the soluble TNF-alpha in the eye? |
|
Definition
|
|
Term
| What antibody is used for antibody-induced disease; it blocks cytokines of inflammation and gets rid of adult B cells that activates T cells that promotes inflammation |
|
Definition
|
|
Term
What can help with TMJ disorders?
What helps with SYMPTOMS of arthritis? |
|
Definition
systemic anti-inflammatory
nonsteroidals |
|
|
