Term
| What are the methods of cell to cell signaling? |
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Definition
Endocrine: Through circulation to distant site
Paracrine: Neighboring cells
Autocrine: Act on self(cytokines, growth factors) |
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Term
| What are the methods of transmembrane signaling |
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Definition
Internal receptors
Cell receptor-> Enzyme activation(Intrinsic or Associated)
Direct Ion channel activation
G-protein coupled receptors |
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Term
| What are major drugs using ligand gated ion channels |
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Definition
Sedatives/Anticonvulsants
Benzodiazepines
Barbiturates
Anesthetics
Muscle Relaxants |
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Term
| What are the effects of activating Gq Gs and Gi |
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Definition
Gq: PLC activation-> IP3, DAG-> Ca2+-> PKC
Gs: Adenylate Cyclase-> cAMP-> PKA
Gi: Inhibits Adenylate Cyclase |
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