Term
Where are the nicotinic and muscarinic receptors found?
What is the mechanism of each recpetor type? |
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Definition
Nm: NMJ
Transient depolarization
Nn: Autonomic ganglia, Adrenal medulla, CNS
Transient depolarization and Increase Ca
M2: Cardiac
Hyperpolarization
M3: SM and Glands
Increase Ca |
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Term
What are the choline esters
Their uses
Contraindications of the class |
|
Definition
Bethanechol: Post-partum, Abdominal Surgery to maintain bladder output
Carbachol: Wide angle Glaucoma
Methacholine: Asthmatic diagnosis
Contraindications:
PUD
Urinary obstruction
Asthma |
|
|
Term
| What are the uses for pilocarpine |
|
Definition
Wide-Angle Glauoma
Stabilize Narrow-Angle with Physostigmine
Xerostomia (radiation or other disease)
|
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Term
What are the tertiary Antimuscarinics?
What are the uses of each? |
|
Definition
Atropine
Acetylcholinesterase inhibitor toxicity
Mydriasis
With diphenoxylate as an Antidiarrheal
Tropicamide
Short-term mydriasis
Scopolamine
Motion Sickness
Tolteridine and Oxybutynin
Overactive Bladder |
|
|
Term
| What are the quaternary Anti-muscarinics and their uses? |
|
Definition
Ipratropium and Tiotropium
Bronchodialation in COPD
Propantheline
GI disturbances
Excessive Sweating |
|
|
Term
| Which anti-cholinergics penetrate the CNS |
|
Definition
Tertiary
Scopolamine
Tropicazamide
Atropine
Oxybutynin, Tolteridine |
|
|
Term
| What drugs have anti-muscarinic activity? |
|
Definition
Tricyclics
Anti-histamines
Typical Anti-psychotics
NMJ Blockers
|
|
|
Term
What is the mechanism of Mecamylamine
What is it used for? |
|
Definition
Non-depolarizing Ganglionic block
Use: Tourette's Syndrome |
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