Term
What are the topical Sulfonamides?
What are the uses of each |
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Definition
Silver Sulfadiazine: Burns
Sulfacetamide: Ocular Infections
Triple Sulfa: Vaginitis(Haemophilus vulgaris) |
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Term
What are the oral sulfonamides?
What are their major uses? |
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Definition
Sulfasoxasole: UTI's
Sulfamethoxazole: Used w/ trimethopirm for UTI's
Sulfadoxine/Pyramethamine: Malaria
Sulfadiazine/Pyramethamine: Toxoplasmosis
Dapsone: Leprosy
Sulfasalasine: IBD (5-aminosalicyclic acid) |
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Term
What is the mechanism of the sulfonamides?
What are the adverse effects?
What is the spectrum? |
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Definition
Mechanism: PABA analog Blocking Dihydropteroate Synthase
Spectrum:
Gram (+)
Gram(-)
Nocardia
Chamydia
Adverse
Hemolytic Anemia in G6P deficient patients
Kernicturus in newborns
Allergic Nephritis
Stephen Johnson |
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Term
| Is trimethoprim or sulfonamides bacteriacidal |
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Definition
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Term
| What specific bacteria species is Trimethoprim and sulfamethoxazole used in combination for? |
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Definition
Pneumocystis Caryni
H. Flu Pneumonia
Strep pneumo Pneumonia
Shigella enteritis
Systemic Salmonella
Systemic Nocardia |
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Term
What is the mechanism of Trimethoprim
What are the major adverse effects of trimethoprim/sulfamethoxazole
How can these be prevented |
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Definition
Mech: Block bacterial dihydrofolate reductase
Adverse
Leukopenia
Megaloblastic Anemia
Prevention: Folate
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Term
What is the mechanism of the Quinolones?
What substances should not be taken with the quinolones?
What are the adverse effects of the quinolones? |
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Definition
Mech: Inhibit Topoisomerase II and IV
Never with anacids
Adverse
Cartilage Damage
Prolonged QT
CNS disturbance |
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