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Fundamentals of Cholinergic Pharmacology
Receptors, their affinities for ACh and their actions
13
Pharmacology
Professional
08/30/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Nicotinic receptors (2 types)
Definition

NN: autonomic ganglia and adrenal medulla

 

NM: neuromuscular junction

 

- both are ligand-gated ion channels

Term

Muscarinic Receptors

  - 2nd messenger systems

Definition

M1, M3, M5:  Gq → PLC → DAG + IP3 → PKC

 

M2, M4: Gi/Go → ↓ adenylate cyclase → ↓ cAMP

Term
M1 tissue expression
Definition

-gastric parietal cells

-peripheral nerves

-some autonomic ganglia (e.g. myenteric plexus)

Term
M2 tissue expression
Definition

-heart

-presynaptic cholinergic neurons

Term
M3 tissue expression
Definition

-exocrine glands

-vascular epithelium

-smooth muscle

Term

Muscarinic receptor agonists

Definition

Pilocarpine

Bethanchol

Carbachol

Term

Muscarinic Receptor Antagonists

Definition

Atropine

Ipratropium

Tiotropium

Scopolamine

Pirenzepine

Tolterodine

Oxybutyinin

Term
Nicotinic Receptor Agonists
Definition

Nicotine

Varenicline

Term
Ganglionic blocking agents
Definition

Mecamylamine

Term
Non-depolarizing neuromuscular blockers
Definition

d-tubocurarine

Doxacurarine

Rocuronium

Atracurium

Mivacurium

Term
Depolarizing Neuromuscular Blockers
Definition

Succinylcholine

Term
Skeletal Muscle Relaxants
Definition

Diazepam

Baclofen

Dantrolene

Term
AChE inhibitors used to treat Alzheimers
Definition

Tacrine

Donepezil

Rivastigmine

Galantamine

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