Term
| Arsenic Poisoning impairs whats enzyme? |
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Definition
| Pyruvate Dehydrogenase (PDH) |
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Term
Pyruvate Carboxylase Deficiency
Symptoms?
What can't be produced? |
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Definition
-epilepsy, ataxia, and lactic acidosis
Can't produce OAA (Oxaloacetate) |
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Term
Pompe Disease
Symptoms?
Biochemical Deficit? |
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Definition
-organomegaly; glycogen accumulation in lysosomes in heart, muscle, and liver
-Loss of lysosomal glucosidase activity |
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Term
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Definition
-deficiency in muscle glycogen phosphorylase
-weakness and cramps |
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Term
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Definition
-Glucose-6-phospatase deficiency
-hypoglycemia, hepatomegaly, hyperlipidemia, hyperuricemia, gouty arthritis, nephrolithiasis, and renal failure |
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Term
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Definition
-shifts O2 saturation curve to the left
-cytochrome oxidase inhibitor |
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Term
| What are the required co-factors for PDHC? |
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Definition
-Niacin
-Lipoic Acid
-Thiamine
-Pantothenate
-Riboflavin |
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Term
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Definition
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Term
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Definition
| block complex IV of the ETC |
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Term
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Definition
| blocks electron flow to Complex III |
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Term
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Definition
| blocks electron flow in Complex I |
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Term
| Three Irreversible Steps of Glycolysis |
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Definition
1) Hexokinase (Glucokinase in liver, pancreas)
Glucose + ATP yields G6P + ADP
2)PFK-1
F6P + ATP yields F 1,6BP + ADP
3)Pyruvate Kinase
PEP + ADP yields pyruvate + ATP |
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Term
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Definition
Activators- PEP, F 1,6 BP
Inhibitors- ATP , alanine
This is for L form, M form doesn't covalent modifiers |
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Term
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Definition
Inhibitors- ATP, Citrate
Activators- AMP, F-2,6-BP |
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