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chemical travels in the blood to cause an effect |
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chemical causes an effect on the cell that secreted it |
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chemical effects adjacent cell |
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Mineralcorticoids: aldosterone Glucocorticoids: cortisol, corticosterone Sex steroids: F: estrogen, progesterone M: androstedione, DHEA, testosterone |
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-polypeptides and peptides -short half life |
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Follicles with follicular cells C cells |
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Parathyroid secretory cells |
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Adrenal gland secretory cells |
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Endocrine pancreas secretory cells |
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alpha, beta, delta F and G cells |
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-Cells of the supraoptic nucleus -Increased water retention by kidneys -posterior pituitary |
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-Cells of paraventricular nucleus -Smooth muscle contractions during lactation and orgasm -Emotional bonding between partners and mother-child -posterior pituitary |
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-Suppresses gonadotropin secretion -Marks circadian rhythms -Epiphysis: pineal gland |
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-C cells -Child: promotes production of bone when levels of Ca too high -thyroid |
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Parathyroid hormone (PTH) 6 |
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-Chief cells -Promotes resorbtion of calcium: • Kidney • Intestine • Osteoclasts -parathyroid |
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-Alpha cells -Release of glucose between meals -exocrine pancreas (pancreatic islets) |
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-Beta cells -Absorption of glucose immediate after meals -exocrine pancreas (pancreatic islets) |
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-Delta cells -Modulates speed of digestion and absorption -exocrine pancreas (pancreatic islets) |
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-F-cells -Inhibitors of gall bladder contraction and secretion of digestive enzymes -exocrine pancreas (pancreatic islets) |
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-G-cells -Promotes stomach function -exocrine pancreas (pancreatic islets) |
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-Premature puberty -Seasonal affective disorder |
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-hypocalcemia with tetany |
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-diabetes mellitus -Type 1: autoimmune -Type 2: increased insulin resistance |
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(GRH) --> FSH pathway females |
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(FSH) from Gonadotropes--> F: ovary (pre- ovulation) -->F: granulosa and theca of follicle -->F. Estrogen--> F: production of estrogen |
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(GRH) -->FSH pathway males |
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Definition
(FSH) from Gonadotropes--> M: testis-->M: sustentacular cells (c. of Sertoli)-->M: sperm production |
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(GRH) --> LH pathway females |
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Luteinizing hormone (LH) from Gonadotropes-->F: ovary (post ovulation)-->F: corpus luteum (Lutein cells)-->F: progesterone-->F: production of progesterone |
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(GRH) --> LH pathway males |
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Luteinizing hormone (LH) from Gonadotropes-->M:testis -->M: Interstitial cells (cells of Leydig)-->M. Testosterone -->M: testosterone production |
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TSH from Thyrotropes-->Thyroid-->Follicular cells -->T4, T3 (T3 more potent) Need iodide--> Child: Development of brain and skeleton Adult: Increased metabolism and appetite -Calorgenic effect |
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Corticotropin releasing hormone (CRH) --> Adenocorticotropic hormone (ACTH) pathway |
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Adenocorticotropic hormone (ACTH) from Corticotropes -->Adrenal cortex, zona fasciculata-->Spongiocytes--> Glucocorticoids-->Long-term stress and tissue remodelling |
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Prolactin inhibiting hormone --> Prolactin pathway |
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Prolactin from Lactotropes --> F: Production of milk M: enhances effect of LH |
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(GHRH) --> (GH) liver pathway |
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Growth hormone from Somatotropes-->Liver production of somatomedines and IGFs-->Infant: promotes growth |
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(GHRH) --> (GH) adrenal pathway |
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Growth hormone from Somatotropes-->Adrenal medulla -->Chromaffin cells-->Adrenaline Noradrenaline Dopamine |
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Child: cretinism or congenital hypothyroidism Adult: hypothyroidism Excess: Hyperthyroidism (myxedema) |
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Prolactin inhibitory hormone pathology |
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Deficit: -Children: pituitary dwarfism Excess: -Children: gigantism -Adults: acromegaly |
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Excess: contributes to shock |
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Testis + tunica vaginalis + tunica albuginea -Seminiferous tubules/interstitial (Leydig) cells -Germinal epithelium -Supporting (Sertoli) cells -Blood-testis barrier -Rete testis |
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-Efferent -Epididymis (head, body, tail) -Ductus defrens |
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• Primordial: follicular c. • Primary: granulosa c. (>1 layer) • Secondary: • +theca: connective tissue secreted by granulosa c. +zona pellucida • Tertiary: follicular fluid • Mature (Graaf): antrum Cumulus ooforus (granulosa c.) Corona radiata • Corpus luteum • Corpus albicans |
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Infundibulum>ampulla>isthmus |
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Fundus>body>cervix: -external and internal os • Perimetrium: squamous epith. • Myometrium: smooth muscle • Endometrium: simple columnar |
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• Fornices • Rugae • Hymen |
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-Spermatic cord • Cremaster • Testicular artery • Pampiniform plexus |
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Broad ligament: fold of peritoneum connecting uterus to pelvic floor Ovaries: mesovarium -ovarian ligament (M) + suspensory ligament (L) Ovariantube: mesosalpinx Uterus: mesometrium -Cardinal: pelvic wall -Uterosacral: sacrum -Round ligament: labium majus |
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Male gonad vascularization |
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Ovarian (Uterine branch) -->Arcuate-->Spiral-->Vaginal |
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Male external genitalia 3 |
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Female external genitalia 4 |
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Mons pubis Labia majus Labia minus Clitoris: prepuce, glans, body, crura |
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Corpus spongiosum: -root bulb, bulbospongiosum Corpus cavernosum: -root: crus to pelvis, ischiocavernosum |
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Clitoris: corpora cavernosa Vestibular bulb: subcutaneus |
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Seminal vesicles: 60% prostiglandins Prostate: 30% Bulbourethral |
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Paraurethral glands Greater vestibular |
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