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Functional Anatomy Final
Endocrine and Reproductive
57
Anatomy
Undergraduate 4
06/05/2013

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Term
Endocrine signaling
Definition
chemical travels in the blood to cause an effect
Term
Autocrine
Definition
chemical causes an effect on the cell that secreted it
Term
Paracrine
Definition
chemical effects adjacent cell
Term
Corticosteroids 11
Definition
Mineralcorticoids: aldosterone
Glucocorticoids: cortisol, corticosterone
Sex steroids:
F: estrogen, progesterone
M: androstedione, DHEA, testosterone
Term
Thyroid hormones 2
Definition
T4, T3
Term
Lipophilic hormones
Definition
needs carrier
Term
Hydrophilic hormones 2
Definition
-polypeptides and peptides
-short half life
Term
Thyroid secretory cells
Definition
Follicles with follicular cells
C cells
Term
Parathyroid secretory cells
Definition
Chief cells
Term
Adrenal gland secretory cells
Definition
spongiocytes
Term
Endocrine pancreas secretory cells
Definition
alpha, beta, delta F and G cells
Term
ADH (vasopressin) 3
Definition
-Cells of the supraoptic nucleus
-Increased water retention by kidneys
-posterior pituitary
Term
Oxytocin 4
Definition
-Cells of paraventricular nucleus
-Smooth muscle contractions during lactation and orgasm
-Emotional bonding between partners and mother-child
-posterior pituitary
Term
Melatonin 3
Definition
-Suppresses gonadotropin secretion
-Marks circadian rhythms
-Epiphysis: pineal gland
Term
Calcitonin 3
Definition
-C cells
-Child: promotes production of bone when levels of Ca too high
-thyroid
Term
Parathyroid hormone (PTH) 6
Definition
-Chief cells
-Promotes resorbtion of calcium:
• Kidney • Intestine • Osteoclasts
-parathyroid
Term
Glucagon 3
Definition
-Alpha cells
-Release of glucose between meals
-exocrine pancreas (pancreatic islets)
Term
Insulin 3
Definition
-Beta cells
-Absorption of glucose immediate after meals
-exocrine pancreas (pancreatic islets)
Term
Somatostatin 3
Definition
-Delta cells
-Modulates speed of digestion and absorption
-exocrine pancreas (pancreatic islets)
Term
Pancreatic polypeptide 3
Definition
-F-cells
-Inhibitors of gall bladder contraction and secretion of digestive enzymes
-exocrine pancreas (pancreatic islets)
Term
Gastrin 3
Definition
-G-cells
-Promotes stomach function
-exocrine pancreas (pancreatic islets)
Term
ADH pathology
Definition
-diabetes insipidus
Term
Oxytocin pathology
Definition
-neglect of infants
Term
Melatonin pathology 2
Definition
-Premature puberty
-Seasonal affective disorder
Term
PTH pathology
Definition
-hypocalcemia with tetany
Term
Insulin pathology 3
Definition
-diabetes mellitus
-Type 1: autoimmune
-Type 2: increased insulin resistance
Term
(GRH) --> FSH pathway females
Definition
(FSH) from Gonadotropes--> F: ovary (pre- ovulation)
-->F: granulosa and theca of follicle -->F. Estrogen-->
F: production of estrogen
Term
(GRH) -->FSH pathway males
Definition
(FSH) from Gonadotropes--> M: testis-->M: sustentacular cells (c. of Sertoli)-->M: sperm production
Term
(GRH) --> LH pathway females
Definition
Luteinizing hormone (LH) from Gonadotropes-->F: ovary (post ovulation)-->F: corpus luteum (Lutein cells)-->F: progesterone-->F: production of progesterone
Term
(GRH) --> LH pathway males
Definition
Luteinizing hormone (LH) from Gonadotropes-->M:testis
-->M: Interstitial cells (cells of Leydig)-->M. Testosterone
-->M: testosterone production
Term
(TRH) --> TSH pathway
Definition
TSH from Thyrotropes-->Thyroid-->Follicular cells
-->T4, T3 (T3 more potent) Need iodide-->
Child: Development of brain and skeleton
Adult: Increased metabolism and appetite
-Calorgenic effect
Term
Corticotropin releasing hormone (CRH) --> Adenocorticotropic hormone (ACTH) pathway
Definition
Adenocorticotropic hormone (ACTH) from Corticotropes
-->Adrenal cortex, zona fasciculata-->Spongiocytes-->
Glucocorticoids-->Long-term stress and tissue remodelling
Term
Prolactin inhibiting hormone --> Prolactin pathway
Definition
Prolactin from Lactotropes -->
F: Production of milk
M: enhances effect of LH
Term
(GHRH) --> (GH) liver pathway
Definition
Growth hormone from Somatotropes-->Liver production of somatomedines and IGFs-->Infant: promotes growth
Term
(GHRH) --> (GH) adrenal pathway
Definition
Growth hormone from Somatotropes-->Adrenal medulla
-->Chromaffin cells-->Adrenaline Noradrenaline Dopamine
Term
GRH pathology
Definition
sterility
Term
TRH pathology 3
Definition
Child: cretinism or congenital hypothyroidism
Adult: hypothyroidism
Excess: Hyperthyroidism (myxedema)
Term
CRH pathology
Definition
Excess: Cushing syndrome
Term
Prolactin inhibitory hormone pathology
Definition
Excess: galactorrhea
Term
GHRH liver pathology
Definition
Deficit:
-Children: pituitary dwarfism
Excess:
-Children: gigantism
-Adults: acromegaly
Term
GHRH adrenal pathology
Definition
Excess: contributes to shock
Term
Testis 9
Definition
Testis + tunica vaginalis + tunica albuginea
 -Seminiferous tubules/interstitial (Leydig) cells
 -Germinal epithelium
 -Supporting (Sertoli) cells
 -Blood-­testis barrier
 -Rete testis
Term
Seminiferous tubules 3
Definition
-Efferent
-Epididymis (head, body, tail)
-Ductus defrens
Term
Ovary follicles 11
Definition
• Primordial: follicular c.
• Primary: granulosa c. (>1 layer)
• Secondary:
  • +theca: connective tissue secreted by granulosa c.
+zona pellucida
• Tertiary: follicular fluid
• Mature (Graaf): antrum
  Cumulus ooforus (granulosa c.)
Corona radiata
• Corpus luteum
• Corpus albicans
Term
Uterine tube 3
Definition
Infundibulum>ampulla>isthmus
Term
Uterus 7
Definition
Fundus>body>cervix:
-external and internal os
• Perimetrium: squamous epith.
• Myometrium: smooth muscle
• Endometrium: simple columnar
Term
Vagina 3
Definition
• Fornices
• Rugae
• Hymen
Term
Testis support 4
Definition
-Spermatic cord
• Cremaster
• Testicular artery
• Pampiniform plexus
Term
Female support 9
Definition
Broad ligament: fold of peritoneum connecting uterus to pelvic floor Ovaries: mesovarium -ovarian ligament (M) + suspensory ligament (L) Ovariantube: mesosalpinx Uterus: mesometrium -Cardinal: pelvic wall -Uterosacral: sacrum -Round ligament: labium majus
Term
Male gonad vascularization
Definition
Testicular artery
Term
Female vascularization 4
Definition
Ovarian (Uterine branch) -->Arcuate-->Spiral-->Vaginal
Term
Male external genitalia 3
Definition
Root>shaft>glans
Term
Female external genitalia 4
Definition
Mons pubis
Labia majus
Labia minus
Clitoris: prepuce, glans, body, crura
Term
Male erectile tissue 6
Definition
Corpus spongiosum:
-root bulb, bulbospongiosum
Corpus cavernosum:
-root: crus to pelvis, ischiocavernosum
Term
Female erectile tissue 2
Definition
Clitoris: corpora cavernosa Vestibular bulb: subcutaneus
Term
Male accessory glands 3
Definition
Seminal vesicles: 60% prostiglandins
Prostate: 30%
Bulbourethral
Term
Female glands 2
Definition
Paraurethral glands
Greater vestibular
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