Term
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Definition
Synthesized by epithelial cells
Entactin binds the two networks together
Lamina Lucida (laminin) & Lamina Densa (type IV collagen) |
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Definition
lamina lucida (Laminin)
lamina densa (type IV Collagen) Ectactin binds these two top layers
and Lamina Reticularis (type III Collagen) - synthesized by cells in underlying connective tissue |
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Term
| Junctional Epidermolysis Bullosa |
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Definition
| rfesults from mutation of laminins or integrins, the epidermis slaughs off the underlying dermis resulting in open wounds and is usually prenatal lethal |
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Term
| Glomerular basement membrane in Kidney |
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Definition
| filtration barrier (specialized) the basal lamina is produced by enothelial cells and epithelial cells on either side. NO LAMINA RETICULARIS. |
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Term
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Definition
| results in a thickening of the basement membrane, caused by glycosylated endproducts. this is specially evident in the kidney, leading to diabeic nephropathy. Also observed in tubular basement membranes. |
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Term
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Definition
High glucose + amino acid (from degradation or metabolism--> ROS + circulating proteins or basement proteins in CT--> Advanced glycated End-products (AGE)--> bind to RAGE->decreased cell potential, lower conduction speeds, generation of ROS--> apoptosis
AGE--> endothelial leakage, thicker BM, generation of immunogenicity |
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Term
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Definition
| in Connective Tissue - collagen, elastin, fibronectin |
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Term
| Collagen Fibers in matrix |
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Definition
most abundant protein in animals, made by fibroblasts and some epithelial cells
provides structural support
linear - (dense regular)tendon or ligament
random - loose connective tissue |
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Term
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Definition
collagen binding domain and cell binding domain for integrin - can span the basement membrane.
Binds to integrin, heparin, collagen, and fibrin |
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Term
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Definition
| Fibers made of the protein elastin, which branch and allow for recoil permits flexibility in tissue and passive recoiling, in arteries, lungs and other tissue requiring expansion and contraction. |
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Term
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Definition
Type I - fibers; skin, bone, ubiquitous
Type II - networks of fibrils; hyaline cartilage, elastic cartilages
Type III - fibers - reticular fibers
Type IV- networks - only found in the lamina densa |
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Term
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Definition
| secreted in chains called procollagen (rich in Gly residues along with proline) made by fibroblasts, the procollagen chain assemble into an linear molecule and cleaved into (insoluble)tropocollagen-->aggregae to form collagen fibrils |
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Term
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Definition
| secreted in chains called procollagen (rich in Gly residues along with proline) made by fibroblasts, the procollagen chain assemble into an linear molecule and cleaved into (insoluble)tropocollagen-->aggregae to form collagen fibrils |
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Term
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Definition
| affects Collagen I/III - brittle bone disease (blue sclera-discoloration of the eyes) |
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Term
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Definition
affects Collagen IV- the basemem membrane deteriorates, allowing proteins and RBCs to enter urine
glomerulonephritis, hearing loss, and end stage kidney disease |
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Term
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Definition
| anti-glomerular basement antibody disease antibody disease, antibdoes attack the lungs and the kidneys. Directed toward alpha 3 NC1 doamin of type IV collagen |
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Term
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Definition
found in spleen, liver, lamina reticularis of the basement membrane
Form a supporting framework for many organs |
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Term
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Definition
| fibrillins cross-link elastin, during aging, fibrillin is degraded and becomes inflexible. |
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Term
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Definition
| pathology of collagen and elastic fiber --> absence of fibrillin --> loss of elastic fibers in the body that can lead to mitral valve prolase (valve can't close normally) and aortic dissection--> inside wall separates from the muscle blood flows through this space |
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Term
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Definition
Proteoglycans - glycosylated proteins = core protein + glycosaminoglycas (GAG) side chains.
Proteoglycan bind to laminin network |
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Term
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Definition
glycosaminoglycans
hyaluronic acid: non-sulfated GAG found in cartilage, skin, wound repair
Chondroitin sulfate: jellylike ground substance of cartilage, bone and blood vessels
Keratin sulfate: GAG found in cartilage, cornea and bone "shock absorber: |
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Term
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Definition
Loose Connective tissue -supports epithelial lining of GI, GU, and respiratory tracts. type I collagen fibers and ground substance (wavy)
Dense Connective tisse |
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Term
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Definition
Regular- tendons and ligaments primarily of type I collagen, composed of collagen fibers and fibroblasts
Irregular- Type I collagen with fibroblasts (all over the place) |
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Term
| Specialized Connective Tissue |
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Definition
Cartilage- jelly like matrix (chondroitin sulface) containing collagen and elastic fibers surrounded by a membrane (perichondrium - some blood vessels)
Bone |
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Term
| Cartilage (has no blood vessels unlike CT) |
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Definition
Hyaline - type II collagen in gel-type matrix, septum of nose, trachea, articular cartilage, surrounded by dense, irregular, vascular connective tissue - perichondrium (joints)
Elastic - surrounded by perichondrium, matrix contains elasic fibers, and chondroitin sulfate - foun in pinna of ear, auditory tube, and epiglottis
Fibrocartilage - contains fewer chondrocytes, usually in rows: no perichondrium - found in intervertebral discs, and ligament-bone attachment of the knee |
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Term
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Definition
matrix becomes calcified due to deposition of hydroxyapatite crystals
contains canalicular system 0 taht connects to lacuane
IT IS VASCULAR and contains nerves |
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Term
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Definition
| the strength of cartilage is due to collagen fibers and the resilience is due to the presence of chondroitin sulfate (chondrocytes in lacuane) |
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Term
| Cancellous Bone vs Compact bone |
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Definition
Cancellous bone -where we find bond marrow, web-like structure
compact bone - dense and no web |
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Definition
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Term
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Definition
| Fibroblasts - secrete both fibers and ground substance of the ECM: derivatives- chondrocytes, osteoblasts, odontoblasts (teeth) |
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Term
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Definition
| can become: chondrocyte (cartilage cell), bone cell (osteoblast/osteocyte), fibroblast, adipocyte, smooth muscle ccells |
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Term
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Definition
| present in bone, tendon, denti, and skkin |
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Term
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Definition
| is present in hyaline and elastic cartilage and syntehsized by chondroblasts |
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Term
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Definition
| is present in bone marrow and lymphoid organs. Synthesized by fibroblasts called reticular cells |
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Term
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Definition
| is synthesized by epithelial cells( only on lamina densa) |
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Term
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Definition
| antigen binds two adjacent IgE receptor mol. (crosslinks)--> induces a signaling cascade resulting in the mobilization of cytosolic Ca2+--? triggers the release of granules storing histamines, proteases, and proteoglycans are released. Cytokines are also synthesized and released |
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Term
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Definition
Eosinophil peroxidase - mings to microorganisms (opsonization)
Major basic protein (MBP) - binds and disrupts the parasite membrane
Eosinophil cationic protein - together with MBP causes fragmentation of parasites |
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Term
Movement of WBCs into the epithelium
(diapedesis) |
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Definition
selectin binds carbs
integrin binds ICAM-1 (epithlium)
matrix metalloproteases break anchoring (degrade and exit) from the blood vessel |
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Term
| Delayed wound healing in Diabetes |
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Definition
| the presence of AFE in the CT, competes with EN-RAGE for binding to RAGE. the CT becomes like glue, preventing the macrophages and fibroblasts from getting to the wound. wound doesn't heal |
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