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FNU Exam 2 Key Points
Pharmacology Summer 2013
74
Pharmacology
Graduate
07/23/2013

Additional Pharmacology Flashcards

 


 

Cards

Term
________ is effective against broad spectrum fungi
Definition
Itraconazole
Term
Itraconazole inhibits
Definition
CYP450
Term
What are the two adverse effects of Itraconazole usage?
Definition
Cardiosuppression and liver damage
Term
Itraconazole inhibits______, which can ____ drugs levels
Definition
CYP3A4 and raise
Term
Itraconazole's absorption can be reduced by
Definition
drugs that reduce gastric aciidity
Term
List two classes of drugs that may reduce gastric acidity?
Definition
H2 antagonists and proton pump inhibitors
Term
In __________, there is a blockage of __________outflow.
Definition
angle-closure glacoma and aqueous humor
*this causes a rise in IOP
Term
If angle-closure glaucoma is not treated, then ___________ to optic nerve occurs in_______
Definition
irreversible damage and 1-2days
Term
What is the major risk factor for open-angle glaucoma?
Definition
elevated IOP
Term
How is drug therapy directed for open-angle glaucoma?
Definition
reduction of IOP
Term
________ is treated with drugs to reduce IOP and surgery
Definition
angle-closure glaucoma
Term
How do drugs reduce IOP?
Definition
facilitating aqueous humor outflow or reducing its production
Term
List the three drug families which are first line tx for open angle-glaucoma.
Definition
beta blockers, alpha2-adrenergic agonists, and prostaglandins
Term
_________ decreases IOP by decreasing ________
Definition
Timolol and aqueous humor production
Term
Topical beta blockers can cause_______, _______, and _______.
Definition
bronchospasm, bradycaria, and AV heart block
Term
__________ may cause browning of the iris and increased pigmentation of the skin around the eyes.
Definition
prostaglandins
Term
What drugs paralyze the ciliary muscle?
Definition
Cycloplegics
Term
Mydriatics _________ the pupil.
Definition
dilate
Term
Atropine and other anticholinergic drugs cause________ and__________
Definition
cycloplegia (ciliary muscle paralysis) and mydriasis (pupil dilation)
Term
How does Atropine cause cycloplegia?
Definition
blocks muscarinic receptors on the ciliary muscle
Term
How does atropine cause mydriasis?
Definition
blocks muscarinic receptors on the iris sphincter
Term
Paralyzing the ciliary muscle with anticholinergic drugs prevents
Definition
near vision
Term
Paralyzing the iris sphincter with anticholinergic drugs causes
Definition
photophobia (the pupils do not constrict to light)
Term
_________ is an adrenergic agonist.
Definition
Phenylephrine
Term
Phenylephrine causes________ by stimulating___________receptors on the radial muscle of the eye.
Definition
mydriasis and alpha-adrenergic
Term
______________ take several weeks to decrease allergy symptoms in eyes
Definition
Ocular mast cell stabilizers
*usu not rx'd bc of this reason
Term
Corticosteroid drops (for eyes) decrease inflammation but may
Definition
mask an infection
*APNs should avoid prescribing these
Term
________ can be used for drys eyes and there are _______ with regular or frequent usage.
Definition
Artificial tears and zero risk
Term
Topical glucocorticoids relieve________ and _________ associated with dermatologic disorders.
Definition
inflammation and itching
Term
What are the four groups of potency classified for glucocorticoids?
Definition
low, medium, high, and super-high
Term
What are the risk of prolonged usage of topical glucorticoids?
Definition
atrophy of the dermis and epidermis
Term
Topical glucorticoids can cause
Definition
systemic toxicity
Term
Growth retardation and adrenal suppression are side effects of
Definition
topical glucorticoids
Term
What promotes shedding of the horny layer of the skin?
Definition
keratolytics
Term
Name three kertolytics.
Definition
salicylic acid, sulfur, and benzoyl peroxide
Term
List three topical antibiotics that tx acne.
Definition
benzoyl peroxide, clindamycin, and erythromycin
Term
How does benzoyl peroxide, clindamycin, and erythromycin work to clear up acne?
Definition
suppresses the growth of propionibacterium acnes
Term
Tretinoin, adapalene, and tazarotene are all
Definition
topical retinoids
Term
Tretinoin, adapalene, and tazarotene clear acne by normalizing__________ of epitheial cells in______.
Definition
hyperproliferation and hair follicles
Term
Retnoids are not
Definition
absorbed systemically
Term
Name a drug reserved for severe acne.
Definition
Isotretinoin (oral)
Term
Nosebleeds, inflammation of the lip and eyes, pain and stiffness of muscle, bones, and joints are all side effects of
Definition
isotretinoin
Term
isotretinoin is highly
Definition
teratogenic
Term
Frequency of the application of _____ reduces the risk of sunburn.
Definition
sunblock
Term
Topical immunosuppressants work against the _________ process of atopic dermatitis.
Definition
inflammatory
Term
Topical immunosuppressants are not_________
Definition
antipruritic
Term
There exist some rare association of cancer in children who have used
Definition
topical immunosuppressants
Term
Children with antibiotic resistant AOM, the tx of choice
Definition
augmentin Es-600 (amoxicillin/clavulanate)
Term
Vaccinating against the flu virus or strept pneumoniae (prevnar) can reduce the risk of
Definition
acute otitis media
Term
Otitis media with effussion (OME) is _________ in the middle ear without________
Definition
fluid and local or systemic illness
Term
OME may cause ______ but not________.
Definition
mild hearing loss and pain
Term
OME is seen in children following
Definition
AOM
Term
OME may last for
Definition
weeks to months
Term
Antibiotics should not be used with____ bc it has minimal effect.
Definition
OME
Term
Otitis externa is inflammation of the
Definition
EAC
Term
What is another name for otitis externa?
Definition
swimmer's ear
*which is a bacterial infection of the EAC
Term
In most cases, acute otitis externa can be tx
Definition
cleaning and use of ear drops
Term
Ears drops to clean/tx acute OE may contain
Definition
alcohol, 2%acetic acid, hydrocortisone, or an antibacterial drug.
Term
Ear drops to treat OE may include
Definition
ciprofloxacin
Term
Preferred antibiotics drops for OE are
Definition
fluroquinolones
Term
The concentration of otic drops are ______ than oral medications
Definition
higher
Term
_________ is a good choice of treatment for adults with OE.
Definition
Cipro
Term
________ is rare but a potentially fatal complication of acute OE
Definition
necrotizing OE
Term
This condition occurs when bacteria in the EAC invaed the mastoid or temporal bone.
Definition
Necrotizing OE
Term
What is the name of the organism responsible for Necrotizing OE?
Definition
pseudomonas aeruginosa
Term
How do you manage Necrotizing OE?
Definition
cleansing and use of antipseudomonal drugs
Term
All pts with necrotizing OE should receive antipseudomonal drugs such as
Definition
ofloxacin solution
Term
Pt with mild cases of necrotizing OE should receive
Definition
oral cipro
Term
Pt with severe cases of necrotizing OE should receive
Definition
IV therapy
-imipenem/cilastatin (primaxin)
Term
The most common fungal pathogen for OE is
Definition
aspergillus
Term
In 10% of OE cases, the infection is due to
Definition
fungi
Term
Fungal OE can be managed by ______ and ________
Definition
cleansing and acidifying drops
-2% acetic acid solution
Term
Topical solutions can be used to fungal OE as well. Name one.
Definition
1% clotrimazole
Term
If fungal OE is unresponsive to typical treatment, then ______ drugs can be initiated.
Definition
oral
-itraconazole and fluconazole
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