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Fluoroquinolones
Fluoroquinolones (FQs)
15
Pharmacology
Professional
08/19/2012

Additional Pharmacology Flashcards

 


 

Cards

Term

MOA of Fluoroquinolones (FQ's)

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Definition

inhibit bacterial DNA topoisomerase IV and inhibits DNA gyrase (topoisomerase II).

Term
Are FQ's concentration dependent or time dependent killing.
Definition
concentration dependent killing.
Term
Name the FQs.
Definition

Ofloxacin (Floxin)

Norfloxacin (Noroxin)

Ciprofloxacin (Cipro, Cipro XR, Proquin XR)

Levofloxacin (Levaquin)

Gatifloxacin (Zymar)

Moxifloxacin (Avelox, Vigamox ophthalmic)

Gemifloxacin (Factive)

Term
Brand name for Ciprofloxacin
Definition

Cipro, Cipro XR, Proquin XR

 

Term
Brand name for Levofloxacin
Definition
Levaquin
Term
Brand name for Moxifloxacin
Definition
Avelox, Vigamox Ophthalmic
Term
Describe the antibiotic activity of Fluoroquinolones
Definition

Extensive activity against gram (-), gram (+) and some atypical coverage.

Term
Black box warning for FQs
Definition

Tendon inflammation and or rupture (most often in Achilies tendon)

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Term
Which of the FQs shouldn't be give thru a NG or other feeding tube.
Definition

Cipro Oral Suspension

 

Note: must also shake (all suspensions) for 15 seconds and not chew the microcapsules

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Term
Which can be given via NG tube?
Definition

Can crush immediate release cipro tablets, mix with water and give via NG tube.

 

Note: hold tube feedings at least 1 hr before and 2 hours after dose.

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Term
When should Proquin XR be given?
Definition
should be given with the main meal of the day, evening meal is preferred.
Term
Dose adjust in renal impairment except for which FQs?
Definition
Moxifloxacin
Term
Can these agents be used in PCN - allergies?
Definition
Yes!
Term

FQs can increase the levels of warfaring, sulfonylureas and QT - prolonging drugs.

 

Probenecid and NSAIDs can increase FQ levels.

 

Definition
Statement. Not a question.
Term
Which FQ is a potent 1A2 inhibitor?
Definition
Cipro!
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