Term
What are the main QN used? |
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Definition
1. Ciprofloxacin (Cipro) 2. Levofloxacin (Levaquin) 3. Moxifloxacin (Avelox) 4. Gemifloxacin (Factive) |
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Term
When QN are combined with Beta lactams, how do you describe the efficacy of the combination? |
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Definition
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Term
Are QN conc dependent or conc independent? |
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Definition
AG and QN are conc dependent |
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Term
QN are mostly used for what? |
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Definition
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Term
Describe the relationship between AG and QN with nephrotoxicity. |
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Definition
AG and QN both cause nephrotoxicity, however, QN induced nephrotoxicity is not as significant and common as AG
- QN are not very soluble and can crystalize and cause tubular necrosis |
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Term
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Definition
1. Selectively inhibit Type II Topoisomerase (DNA Gyrase and Topoisomerase IV) |
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Term
For gram (-) organisms, what is the primary target? |
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Definition
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Term
For gram (+) organisms, what is the primary target? |
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Definition
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Term
What happens when you inhibit Topoisomerase IV? |
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Definition
Strand separation problems |
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Term
What happens when you inhibit DNA Gyrase? |
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Definition
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Term
What are we trying to do with the newer QN? |
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Definition
We are starting to manipulate the placement of fluoride to target DNA Gyrase or Topoisomerase IV |
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Term
How many generations of QN do we have? |
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Definition
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Term
What are the enzyme subunit and gene that codes for DNA Gyrase? |
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Definition
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Term
What are the enzyme subunit and gene that codes for Topoisomerase IV? |
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Definition
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Term
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Definition
The oldest QN is CIPRO, then ofloxacin |
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Term
Cipro dominates which part of the market? |
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Definition
Gram neg: Enterobacter, klebsiella, ecoli (sucks at targeting strep pneumo) |
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Term
Levoquin dominates which part of the market? |
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Definition
Gram pos (particularly CAP) |
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Term
What is classified as a normal QN? |
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Definition
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Term
What is classified as respiratory QN? |
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Definition
Levo, Moxi, Gemi - very selective for CAP bc these drugs are highly potent against strep pneumo which is the most common cause of CAP, COPD exacerbations, sinusitis)
Gram (+): Legionella, H. pneumoniae, Chlamydia/Mycoplasma pneumonia |
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Term
What is the advantage of QN? |
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Definition
They cover atypicals bc not all bacteria have peptidoglycan but all bacteria uses DNA Gyrase or Topoisomerase IV |
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Term
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Definition
One simple mutation is all it takes for resistance |
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Term
What are the mechanisms of resistance for QN? |
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Definition
1. Chromosomal - gyrA/B or parC/E mutations - different QN have diff affinity for enzymes - changes in binding affinity = increased MIC - Gram (-) organisms seem to be more gyrA mutation prone 2. Permeability alterations - seems to be mostly observed with gram (-) organisms - the outer cell wall is altered or the porin expression is decreased - QN target is in the cell and drug is unable to reach target or does so at lower than effective levels 3. Efflux - transport QN and other antibiotics out of the cell - associated with low to intermediate resistance |
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Term
How can you eliminate QN resistance? |
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Definition
By targeting 8-10 times above the MIC, bc these are conc dependent killing however, limited by seizures and nephrotoxicity |
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Term
What is a disadvantage of PO QN? |
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Definition
QN bind to Ca, VitD, and Mg, so the bioavailability of QN can be decrease when taken along with enteral feedings, antacids, Ensure, milk |
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Term
How do you decrease resistance to QN? |
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Definition
1. If initial MIC testing values are elevated, use max tolerated QN dose 2. Limit the use of QN in the animal population 3. Resistance can be eliminated for QN if the drug conc is 8-10x the MIC 4. Avoid interactions that decrease oral F |
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Term
What is the max MIC killing? |
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Definition
Max killing occurs at 15-20x MIC |
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Term
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Definition
1. Widely distributes to most body tissues 2. Cipro, Levo, Moxi obtain good conc in the liver, kidneys, feces, prostate, lungs, sinuses 3. Moxi is 50% metabolized by glucoronidation/sulfate conjugation, high fraction of drug eliminated via feces 4. Tissue conc > plasma 5. High intracellular concentrations |
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Term
What level of AUIC do you need for gram (+/-) to be effective? |
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Definition
Gram (+): AUIC > 30 Gram (-): AUIC > 125 |
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Term
What level of AUIC is needed to prevent resistance for gram (+/-)? |
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Definition
Gram (+): AUIC > 50 Gram (-): AUIC > 100 Peak:MIC > 10:1 |
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Term
Do QN have post-antibiotic effect? |
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Definition
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Term
Which QN is used mostly for UTI? |
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Definition
Cipro and Levo - highest urine conc (Cipro most used when SPACE is suspected) |
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Term
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Definition
1. Increased Gram (-) coverage |
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Term
What can't Cipro be used for? |
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Definition
Never recommend Cipro for Pneumococcus |
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Term
Cipro has poor activity against what? |
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Definition
Cipro is poor against Enterococcus |
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Term
Cipro is combined with what for intra-abdominal infections? |
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Definition
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Term
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Definition
Increased (+) coverage: S. pneumoniae, S. aureus - Will work for MSSA, variable activity with MRSA - E. faecalis coverage is good, E. faecium coverage is not reliable (Amp & Gent for E. faecalis) - Listeria coverage is good |
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Term
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Definition
1. Increased anaerobic coverage 2. Some use in intra-abdominal infections 3. Retains gram (+) activity |
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Term
Gemi and Moxi are mostly used for what? |
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Definition
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Term
What is the only oral anti-pseudomonal drug? |
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Definition
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Term
For serious infections, do you want to use QN? |
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Definition
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Term
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Definition
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Term
What options do you have for drug resistant strep pneumo? |
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Definition
1. Gemi 2. Moxi 3. Ceftriaxone 4. Cefitaxime 5. Ceftaroline |
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Term
What does QN have poor to moderate activity against? |
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Definition
1. S. aureus 2. S. epidermidis 3. Resistance to staph develops rapidly 4. MRSA/MRSE coverage overall is rather poor 5. Moderately active in combination for Mycobacterium infections |
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Term
What does QN have excellent activity against? |
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Definition
1. Enterobacteriaceae 2. H. ducreyii 3. H. influenza 4. M. catarrhalis 5. Moxi and Gemi have increased Strep activity 6. N. gonorrhea resistance has increased 7. Covers atypicals: Chlamydia, Mycoplasma, Legionella |
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Term
How do you treat Pseudomonas aeruginosa UTI? |
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Definition
Cipro & Levo are adequate alone |
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Term
What is the efficacy against Pseudomonas? What are their MIC? |
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Definition
Cipro > Gemi = moxi > Levo
MIC Cipro = 4; Gemi = 4-5; Moxi = 8; Levo = 16 |
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Term
What is the efficacy against S. pneumoniae? |
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Definition
Gemi > Moxi > Levo MIC Gemi < 0.03, Moxi <.25, Levo 1 |
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Term
What is the efficacy of Staph aureus? |
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Definition
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Term
Which QN has efficacy against anearobes? |
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Definition
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Term
Which QN can be used for intra-abdominal infections? |
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Definition
Cipro and Moxi but Cipro doesnt have anaerobic cover so must be combined with flagyl |
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Term
Should QN be combined with AG for double coverage? |
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Definition
NO! No synergy or additive effects |
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Term
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Definition
Yes, QN are rarely d/c bc of ADR |
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Term
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Definition
1. GI 2. CNS 3. Dermatologic 4. Renal 5. Arthropathy 6. Tendonitis of Achilles, shoulder & hand 7. Chondrotoxicity 8. Vasculitis 9. Cardiotoxicity prolongation 10. Hypo/hyperglycemia 11. Teratogenicity
(Gee, CDR are ATC, VCr Have to be Tossed) |
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Term
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Definition
1. Multi-valent cation-containing products: Al, Mg, Ca, Fe, Zn 2. Sucralfate (aluminum gum) 3. Cimetidine (decreases tubular secretion of renally eliminated QN: cipro, levo) 4. Didanosine: Buffered by Al carbonate and MgOH 5. Theophylline/Caffeine (CYP1A2 interaction: Cipro) 6. Warfarin: Cipro/Levo 7. Foscarnet 8. QT prolonging medications - Amiodarone, atypical antipsychotics, TCAs, TKIs |
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Term
What would you use for complicated Pseudomonal UTI? |
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Definition
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Term
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Definition
1. Drug resistant strep pneumo 2. Complicated pseudomonal UTI 3. Prostate infections |
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Term
What are alternative uses of QN? |
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Definition
1. Traveler's Diarrhea 2. Osteomyelitis 3. Otitis media 4. Bioterrorism related anthrax post exposure prophylaxis 5. Empiric therapy for severe CAP in a high risk patient or those requiring hospitalization |
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Term
What are some patient counseling tips? |
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Definition
1. Finish all medication 2. Minimize UV exposure 3. Hydrate/water 4. Bioavailability issues & arthropathy |
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