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Fluids, Electrolytes, Acids and Bases
Ch. 4
40
Pathology
Undergraduate 3
09/14/2010

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Term
Respiration Alkalosis
Definition
Occurs when there is alveolar hyperventilation and excessive reduction in plasma CO2 levels
Term
Respiratory Acidosis
Definition
Decrease in alveolar ventilation in relation to the metabolic production of CO2
Term
Metabolic Alkalosis
Definition
Excessive loss of metabolic acids occurs, bicarbonate increases
Term
Metabolic Acidosis
Definition
Non-carbonic acids increase or bicarbonate is lost from ECF
Term
Alkalemia
Definition
pH of arterial blood greater than 7.4
Term
Acidemia
Definition
pH of arterial blood less than 7.4
Term
Correction
Definition
Occurs when the valves for both components of the buffer pair return to normal
Term
Compensation
Definition
Renal and respiratory adjustments to pH
Term
Non-volatile
Definition
Can be eliminated by the kidney
Term
Volatile
Definition
Can be eliminated as CO2 gas
Term
Hyperkalemia
Definition
Elevation of ECF K+ above 5.5 mEq/L
Term
Hypokalemia
Definition
K+ deficiency below 3.5mEq/L
Term
Potassium
Definition

Major intracellular electrolyte

4000mEq

Predominant ICF ion

Term
Hypochloremia
Definition
Result of hyponatremia or elevated bicarbonate conc.
Term
Syndrome of Inadequate Secretion of ADH
Definition
SIADH
Term
Hypovolemia
Definition
Pure Na losses may be accompanied by loss of ECF, causing isotonic ____
Term
Hypertonic Hyponatremia
Definition
Develops w/ hyperlipidemia, hyperproteinemia, and hyperglycemia
Term
Dilutional Hyponatremia
Definition
Occur when the proportion of TBW to total body Na+ is excessive
Term
Hyponatremia
Definition
Develops when the serum Na+ conc. is below 135 mEq/L
Term
Hypernatremia
Definition
Develops when serum Na+ levels exceed 147 mEq/L
Term
Hyperchloremia
Definition
Occurs clinically when there is too much Na+ or too little bicarbonate
Term
Isotonic Fluid Excess
Definition
Result of excessive administration of intravenous fluids, hypersecretion of aldosterone, or drug effects
Term

Isotonic Fluid Loss

-dehydration

Definition
Causes contraction of the ECF vol. w/ weight loss, dryness of skin, and mucous membranes, decrease urine output, and symptoms of hypovolemia
Term
Natriuretic Hormone
Definition

Promote urinary excretion of Na+ and water and decrease in blood pressure

"third factor"

Term
Renin
Definition
Enzyme secreted by the juxtaglomerular cells of the kidney
Term
Aldosterone
Definition

Mediates hormonal regulation of Na+ balance

Secreted by adrenal cortex

Term
Chloride
Definition

Major anion in ECF

Provides neutrality

Term
Sodium
Definition

Accounts for 90% of the ECF cations

Regulates osmotic forces and water balance

Important in regulation of osmolarity

Term
Baroceptors
Definition
Located in the aorta, pulmonary arteries, and cartoid sinus
Term
Volume Sensitive Receptors
Definition
Located in the right and left atria and thoracic vessels
Term
Osmoreceptors
Definition
Neurons in hypotalamus
Term

ADH (Anti-diuretic hormone)

Perception of thirst

Definition
Water balance regulated by _____ and ____
Term
Lymphedema
Definition
Blocking of lymphatic channels or surgical removal causing proteins and fluid to accumulate in the interstitial space
Term
Edema
Definition
Accumulation of fluid w/ in the interstitial spaces
Term
Starling's Hypothesis
Definition
Net filtration= force favoring filtration- force opposing filtration
Term
Net Filtration
Definition
Movement of fluid back and forth across capillary wall
Term
ICF Osmotic Balance
Definition
K+
Term
ECF Osmotic Balance
Definition
Na+
Term
Osmosis
Definition
Water moves as a function of _____
Term
TBW (60%)
Definition

Total Body Water

_____% of body weight

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