Term
what type of receptors are 5HT-R? |
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Definition
all are metabotropic, except 5HT3 - ionotropic |
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Term
5HT-1A, drug suffix? drug action? use? examples? |
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Definition
pirone/pidil agonists anxiety and hypertension Buspirone, Urapidil |
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Term
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Definition
5HT-1A agonist also alpha-1 adrenergic antagonist |
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Term
Buspirone, action? onset? use? |
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Definition
5HT-1A agonist, moderate D2 affinity, 5HT-2 agonist onset 4-6 weeks, months for full effect chronic anxiety |
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Term
5HT-1D/F, drug suffix? drug action? use? |
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Definition
triptan agonists Migraine - cerebral vasoconstriction and anti-inflammatory |
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Term
what is the main difference between the various "triptans"? |
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Definition
t1/2 and metabolism - most by MAO-A, naratriptan by CYP enzymes |
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Term
what is the most efficacious triptan? administration efficacy? |
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Definition
sumatriptan subcutaneous > nasal > oral |
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Term
triptans are contraindicated in which patients? why? |
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Definition
cardiovascular disease they are vasoconstrictors and will increase BP |
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Term
what drug interactions are possible with triptans? why? |
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Definition
MAO-I because triptans are metabolized by MAO-A |
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Term
MAO-A metabolizes what? MAO-B |
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Definition
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Term
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Definition
MAO-A and B inhibitor - antidepressant |
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Term
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Definition
MAO-A and B inhibitor - anti-Parkinsons |
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Term
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Definition
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Term
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Definition
5HT-2 antagonist and H1 antagonist migraines |
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Term
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Definition
5HT-2 antagonist anxiety and depression |
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Term
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Definition
5HT-2 antagonist anxiety and depression |
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Term
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Definition
5HT2 antagonist and alpha1-blocker hypertension, Raynaud's (spasm of femoral artery) |
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Term
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Definition
5HT2 antagonist and SSRI antidepressant off market - liver damage |
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Term
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Definition
5HT2 and SSRI antidepressent still on market |
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Term
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Definition
5HT2 antagonist and D2 blocker (equally) antipsychotic |
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Term
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Definition
5HT2 antagonist > D2 blocker antipsychotic |
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Term
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Definition
5HT2 antagonist >>> D2 blocker antipsychotic |
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Term
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Definition
5HT2 antagonist and 5HT-1A agonist antipsychotic no weight gain or risk of torsades |
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Term
5HT3, drug suffix, drug action, use |
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Definition
setrons antagonist anti-emesis, diarrhea, IBS |
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Term
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Definition
5HT3 antagonist extremely long acting given i.v. once before each cycle of chemotherapy |
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Term
5HT-4, drug suffix, drug action, use |
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Definition
pride agonist (increase ACh) gastroparesis |
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Term
metoclopramide; action, use, SEs |
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Definition
5HT-4 agonist, D2 agonist, 5HT-3 antagonist, cholinesterase inhibitor anti-nausea and vomiting tarditive dyskinesia |
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Term
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Definition
5HT-4 agonist off market - interfered with K-channel blockers -> torsades |
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Term
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Definition
5HT-4 agonist essentially cisapride w/o K-blockage |
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Term
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Definition
delayed ejaculation and hyperthermia |
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Term
which SSRIs don't inhibit CYP P450 enzymes |
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Definition
citalopram and sertraline |
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Term
what is the most popular SSRI? why? |
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Definition
citalopram, it is the most selective for 5HT, and has minimal P450 inhibition |
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Term
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Definition
essentially a tricyclic antidepressant without the SEs |
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