Term
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Definition
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Term
| PPAR-alpha mechanism of action |
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Definition
| dimerizes w/ RXR -> migration to nucleus -> bind to PP-response element on DNA -> transcription of gene for lipoprotein lipase (FA catabolism) |
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Term
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Definition
| prostaglandins, leukotrienes and "-glitazones" |
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Term
| PPAR-gamma mechanism of action |
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Definition
| dimerizes w/ RXR -> migration to nucleus -> binding with PP-response element -> transcription of genes involved in storage of FAs and others -> increased insulin sensitivity |
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Term
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Definition
fibric acid derivatives
all end in -fibrate EXCEPT gemfibrizol
activate PPAR-alpha
main effect - Decrease TGs
SEs - when combined w/ statins -> rhabdomyolysis -> renal failure |
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Term
| -glitazones, effect? SEs? benefits? |
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Definition
thiazolidinediones
activate PPAR-gamma
Tx of Type II DM - improved sensitivity to insulin
some affinity for PPAR alpha, so also decrease TGs
SEs - edema and heart failure
*do not cause hypoglycemia (like SUs and repaglinide), but slow onset |
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Term
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Definition
glycated hemoglobin
provide estimate of blood sugar over past 3-4 months
HbA1C < 7 (= average blood sugar of 150mg/dl) |
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