Term
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Definition
○ Administration
○ Liberation
○ Absorption
○ Distribution
○ Metabolism
○ Excretion |
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Term
| what is absorbed in stomach? intestines? |
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Definition
stomach - weak acids
intestine - weak bases |
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Term
| uses of Na-channel blockers? |
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Definition
| local anesthetics, Anti-arrhythmics, anti-epileptics |
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Term
| Ester LAs, 1/2 life? metabolism?examples? |
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Definition
-short 1/2 life, rapid metabolism by plasma esterases
-procaine and cocaine |
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Term
| amide LAs; 1/2 life? metabolism? examples? |
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Definition
-longer 1/2 life, hepatic metabolism
-lidocaine, etidocaine, prilocaine (2 "i"s in name) |
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Term
| 5 Vaughan-Williams classes of anti-arrhythmics |
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Definition
I - Na channel blockers
II - beta blockers
III - K channel blockers
IV - Ca channel blockers
V - vagus boosters |
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Term
| VW class IA; action? ex's? |
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Definition
decrease pohase 0 and decrease phase 3
can result in tosade de pointe
quinidine, procainamide, disopyramide |
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Term
| VW class IB; action? ex's? |
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Definition
-decrease phase 0 and increase phase 3
-Lidocaine, mexiletine |
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Term
| VW class IC; action? ex's? |
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Definition
-decrease phase 0, no effect on phase 3
-flecainide |
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Term
| carbemazipine; type? channel? SEs (and cause)? |
|
Definition
Anti-epileptic
Na channel blocker - membrane stabilization
CYP P450 3A4 inducer
SEs (similar to TCA)
sedation - H1 receptorblocker
dry mouth - M-receptor blocker
arrhythmia Na and K channel blocker
hypotension - alpha-R blocker
weight gain - 5-HT |
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Term
|
Definition
| Ca blockers, statins, macrolide antibiotics, benzodiazepines, HIV antivirals, antihistamines |
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Term
| Phenytoin; type? channel? SEs? |
|
Definition
anti-epileptic Na and Ca channel blocker
CYP 3A4 inducer
0 order kinetics
SEs - gum hyperplasia, megaloblastic anemia, folate/B12 deficiency, peripheral neuropathy, skin rash, hirsuitism |
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Term
| substrates w/ saturabale hepatic metabolism (zero order kinetics) |
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Definition
| ethanol, ASA (aspirin), heparin, Theophyllin, phenytoin |
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Term
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Definition
| triamterene, dapsone, phenytoin, trimethoprim, methotrexate |
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Term
|
Definition
Na channel blocker
LA ester |
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Term
| lidocaine; channel? type? |
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Definition
Na channel blocker
LA amide and VW Class IB anti-arrhythmic |
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Term
| quinidine; action? type? SEs? |
|
Definition
Na channel blocker
VW Class IA anti-arrhythmics
atropine-like effects (anticholinergic)
SEs - cinchonism (blurred vision, tinnitus, headaches) increased digoxin leves, N & V, arrhythmia |
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Term
| procainamide; action? type? |
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Definition
"VW class IA"
technically it is a VW IC (Na blocker only) but is metabolized to NAPA, a VW class III (K-blocker)
*fast metabolizers at higher risk for torsades de pointes |
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Term
| flecainide; action? type? |
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Definition
Na channel blocker
VW class IC anti-arrhythmic |
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Term
| what causes the following SEs? sedation, dry mouth, arrhythmia, hypotension, weight gain |
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Definition
sedation - H1 (histamine) blocker
dry mouth - Muscarinic receptor blocker
arrhythmia - Na or K channel blocker
Hypotension - Alpha-R blocker
Weight gain - 5-HT (seratonin) |
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