Term
| Lente or L-type; describe, use, blockers |
|
Definition
slow channels
for supraventricular arrhythmias
Verapamil, diltiazem, nifedipine |
|
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Term
| Transient or T-type; describe, use, blockers |
|
Definition
fast channels (only open briefly)
anti-seizure meds
ethosuximide, methsuximide, zonisamide, valproylamide, phenytoin |
|
|
Term
|
Definition
Decrease NT release
for chronic pain
Gabapentin and pregabalin |
|
|
Term
| verapamil; type? action? use? SEs? |
|
Definition
non-selective (cardiac vs. vascular) L-type CaCB
decreases HR and O2 Uses - supraventricular arrhythmia SEs - constipation, edema, increased digoxin levels |
|
|
Term
| Nifedipine; type? action? T1/2? |
|
Definition
vascular L-type CaCB
lower blood pressure
arteriole vasodilator - decreases afterload
3-4hr, halflife |
|
|
Term
| Diltiazem; type? action? use? |
|
Definition
L-type CaCB
Decreases HR and 02 demand
Use - coronary artery vasospasm |
|
|
Term
|
Definition
T-type CaCB
Use - absanes petite mal seizures |
|
|
Term
|
Definition
T-type CaCB
use - absence (petit mal) seizures |
|
|
Term
|
Definition
T-type CaCB
Mixed mode of action (MOA) drug |
|
|
Term
|
Definition
T-type CaCB
anti-seizure
Mixed mode of action (MOA) drug |
|
|
Term
|
Definition
T-type CaCB (NaCB and CaCB)
anti-seizure med
CYP 3A4 inducer
SEs - gum hyperplasia, Hirsuitism, folate deficiency, megaloblastic anemia, rash, peripheral neuropathy |
|
|
Term
| pregabalin and gabapentin |
|
Definition
N-type/NPQR
reduce NT release
use - chronic pain |
|
|
Term
|
Definition
Ryanodine Receptor blocker
inhibits release of intracellular Ca from skeletal muscle sarcoplasmic reticulum
use- malignant hyperthermia |
|
|
