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Final
Lecture 1
47
Architecture
8th Grade
12/01/2012

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Cards

Term
SLE is a _ multisystem disease
Definition
collagen-vascular
Term
lupus erthmeateux means it occurs where?
Definition
in skin
Term
SLE is autoantibody production to what?
Definition
nuclear components
Term
how mnay criteria are needed for diagnosis of SLE?
Definition
4 out of 11
Term
how many cases per 100,000 ppl
Definition
50
Term
more in women or men?
Definition
women
Term
between what ages is it diagnosed
Definition
15-45
Term
the etiology of SLE is still
Definition
unknown
Term
how mnay susceptibility genes are required for expression of lupus
Definition
4
Term
1st degreee relatives of SLE person is _ times likely to get SLE
Definition
20
Term
triggering env factors (3)
Definition
sunlight, hydazine, aromatic amines
Term
what virus may cause SLE
Definition
Epstein BArr
Term
what sex hormone inhibits expression?
which enhances?
Definition
androgen
estrogen
Term
SLE has production of abnormal amount of what?
this leads to increase?
Definition
autoantibodies
immune complexes
Term
excess autoantibodies comes from hyperactive?
Definition
B lymphocytes
Term
t cells switch types from what to what?
Definition
Helper 1-> helper 2
Term
antibodies to what kind of DNA is in 80% of SLE
Definition
double stranded
Term
what 4 RNA associated antigens are in SLE
Definition
smith, snRNP, Ro, La
Term
antibodies to what make up the lupus anticoagulant
Definition
phospholipid part of prothrombin activator
Term
what make up the antiphospholipid antibodies
Definition
lupud anticoag and anticardiolipin
Term
what 4 types fo antiboides are present many years before SLE diagnosis
Definition
Antinuclear, Anti-Ro, Anti-La, antiphospholipids
Term
what 2 types of antibodies are only months before diagnosis
Definition
ANti-SM, anti-snRNP
Term
some common signs of SLE
Definition
anorexia, fatigue
Term
what body system is invovled usually
Definition
musculoskeletal
Term
what joints may be affected?
Definition
all
Term
butterfly rash is in _% of patients
Definition
50
Term
discoid lupus is in _% of patients
Definition
20
Term
a common cutaneous manifestation besides butterfly rash it
Definition
vasculitis
Term
what is a common pulmonary infection with lupus
Definition
pneumonitis
Term
cardiac manisfestation usually present as
Definition
pericarditis
Term
what cardiac problem is seen more as life expectancy increases
Definition
CAD
Term
GI problems include (2)
Definition
nausea, abdominal pain
Term
what hematologic problems= occurs in disease exacerbation
Definition
thrombocyto
Term
what is a commen hematoglic problem
Definition
leukopenia
Term
lupus nephritis is associated with increased risk of
Definition
morbidity/mortality
Term
what stage of lupus nephritis has sceloritc lesions >50%
Definition
III-Focal
Term
what diagnostic test is for SLE?
if it presents with _ its positive for SLE?
Definition
ANA
peripheral pattiern (rim)
Term
For SLE diagnosis the antigen for peripheral is
Definition
dsDNA
Term
For SLE diagnosis the antigen for speckled
Definition
ribonucleoprotein
Term
For SLE drug induced diagnosis the antigen for homomgenous
Definition
histones
Term
what are the 3 main causes of death
Definition
complications of treatment, CAD, infection
Term
manisfestations that can be handled with antimalarials are
Definition
cutaneous
Term
what type and when do you use steroid therapy
Definition
pulse
remission if have life threatening disease
Term
drugs indicated fro inducing SLE (4)
Definition
chlorpromazine
minocycline
methyldopa
quinidine
Term
what is gold standard treatment for lupus nephritis and severe lupus
Definition
cyclophosamide + methyl prednisolone
Term
what is the active metabolite of azothioprine
Definition
6-mercaptopurine
Term
MOA of azothioprine involves what 2 paths
Definition
block purine synth
T cell apoptosis
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