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Final Review
Rapid Review
112
Biology
Graduate
04/12/2012
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Term
Adesine
 Definition
Purogenic (P1)
Term
Vagal Nerve Stimulation
 Definition
ACh (M2/betagamma) (affects Ik.ach)
Term
Gilberts disease
 Definition
decreased UGT for irinotecan toxicity
Term
Neonates
 Definition
decreased UGT
Term
Grey Baby Syndrome
 Definition
Chlorimphenicol
Term
Celiacs
 Definition
decreased absorption
Term
Starvation/Malnutrition
 Definition
decreased protein bound
Term
Whipples Disease
 Definition
Decreased Absoprtion
Term
Phase I
 Definition
oxidation
Term
Phase II
 Definition
conjugation
Term
Codiene
 Definition
2D6
Term
Clopidrogel
 Definition
2C19
Term
Warfarin
 Definition
CYP2C9/VKORC1
Term
Ethanol Induction
 Definition
2E1
Term
Terfenadine
 Definition
CYP3A4
Term
6-MP
 Definition
TPMT
Term
St. Johns Wort
 Definition
CYP3A4 induction
Term
Ginkgo
 Definition
Bleeding
Term
Metyrosine
 Definition
Blocks Tyrosine hydroxylase
Term
Reserpine
 Definition
Blocks vesicle packaging
Term
Guanethidine
 Definition
Blocks vesicle release
Term
Prazosin
 Definition
alpha blocker
Term
propranolol
 Definition
Beta blocker
Term
Pseudoephedrine/Aphetomine
 Definition
displacement from vesicle
Term
Cocaine
 Definition
block Uptake 1
Term
Epi
 Definition
increase alpha 1/2 and beta 1/2
Term
Norepi
 Definition
increase alpha 1/2 and beta1
Term
Isoproterenol
 Definition
increase beta 1/2
Term
Phenylephrine
 Definition
increase alpha 1 (1>2)
Term
Albuterol
 Definition
increase beta2
Term
Clonidine
 Definition
increase alpha2
Term
Prazosin
 Definition
decrease alpha1
Term
Atenolol
 Definition
decrease beta1
Term
Nebivolol
 Definition
beta1 and vasodilation
Term
TCA
 Definition
block uptake 1
Term
Deprenyl
 Definition
block MAO-B (irreversible)
Term
Tyramine
 Definition
Displacement from vesicle
concern with taking MAO-I
Term
Hemicholinium
 Definition
block choline intake
Term
Vesamicol
 Definition
block vesicle packaging
Term
Snake/spider venom
 Definition
vesicle destruction
Term
3,4-diaminopyridine
 Definition
Enhance vesicle release
Term
Bethanecol
 Definition
muscarinic agonist
Term
Atropine
 Definition
muscarinic blocker
Term
Scopolamine
 Definition
anti-emetic (anticholinergic -- muscarinic blocker
Term
Curare
 Definition
non-depolarizing flacid paralysis -- nicotinic blocker
Term
Succinylcholine
 Definition
depolarizing nicotinic blocker
Term
malignant hyperthermia
 Definition
dantrolene
Term
Edrophonium
 Definition
Aceytylcholinesterase inhibitor reversible
Term
Neostigmine
 Definition
block AChE -- increase Ach at the synapse
Term
Physostigmine
 Definition
block AChE -- increase Ach at the synapse -- atropine posioning
Term
Organophosphates
 Definition
-- block AChE IRREVERS
Term
Nortryptylin
 Definition
TCA
Term
Amitriptyline
 Definition
Amitriptyline
Term
Fluoxetine
 Definition
SSRI -- seretonin syndrome/toxidrome with MAOi -- hyperthermia, muscle rigidity
Term
Sertraline
 Definition
SSRI
Term
Mirtazapine
 Definition
sedation and weight gain
Term
Wine and cheesse syndrome
 Definition
Selegiline
Term
Haloperidol
 Definition
typical anti-psychotics -- tarditive dyskonesia
Term
agranulocytosis
 Definition
Clozapine
Term
Lorazepam/Benzodiazepines
 Definition
GABAa increase freq.
Term
Phenobarbital/Barbituates
 Definition
GABAa increase duration
Term
Methadone
 Definition
mu-opiod receptor agonist
Term
Fentayl
 Definition
mu-opiod receptor agonist
Term
Nalaxone
 Definition
mu-opiod receptor antagonist
Term
Opiate
 Definition
respiratory suppression
Term
Nausea/Emesis prophylaxis only
 Definition
DEXAMETHASONE
Term
helpatotoxicity
 Definition
Halothane
Term
Undesirable psyc effects
 Definition
ketamine
Term
greatest hepatic metaboism
 Definition
halothane
Term
Phenytoin
 Definition
Na
Term
Ethosuximide
 Definition
Ca (ttype)
Term
Phenobarbital
 Definition
GABA duration
Term
Ethanol
 Definition
Osmol Gap
Term
Methanol
 Definition
metabolic acidosis, anion gap // visual disturbances
-OD: ethanol
Term
Isopropanolol
 Definition
serum acetone
Term
Ethylene glycol
 Definition
anion gap, urine oxalate // renal failure
-OD: ethanol
Term
Benzodiazepine OD
 Definition
flumazenil
Term
Digoxin OD
 Definition
digibind
Term
iron od
 Definition
Deferoxamine
Term
loss of consciousness, slurred speech, brady, hypoten, pinpoint pupils
 Definition
Sedative
Term
restlessness, tremor, tachy, insomnia, wide pupils
 Definition
Stimulant
Term
tremor, hyperreflexia, sweating, fever, tachycardia, agitation, wide pupils, rapid respiration
 Definition
Serotonin
Term
fluxh, dryskin, hyperthermia, tachy, urinary retention
 Definition
Anti-cholinergic
Term
Reye's syndrome and GI bleed
 Definition
ASA
Term
APAP
 Definition
NAPQI
Term
H1
 Definition
-- Gq
-First Gen sedating
-Second Gen not
Term
H2
 Definition
Gs
Term
Naproxen/Ibuprofen
 Definition
reversible
Term
Salicylates/Asprin
 Definition
NOT REVERSIBLE
Term
Deiphenhydramine/dimenhydramate
 Definition
H1 first gen
Term
Loratedine
 Definition
H1 2nd gen antagonist
Term
Fexofenadine
 Definition
H1 blocker 2nd gen antagonist
Term
Cimetidine
 Definition
H2 blocker
Term
Montelukast SE
 Definition
CHURG STRAUSS SYNDROME
Term
corticosteroids not chronic dose orally
 Definition
-osteoporisis
-itragenic cushing
Term
corticosteroids not chronic dose orally
 Definition
-osteoporisis
-itragenic cushing
Term
Leflunomide
 Definition
block pyrimidine synthesis
Term
Methotrexate
 Definition
blocks purine synthesis
Term
Infliximab
 Definition
Antibody that binds TNFalpha
Term
Ethanercept
 Definition
Fusion protein to bind TNFalpha
Term
Indomethacine
 Definition
COX 1/2 inhibitor / reversible - Closes PDA
Term
Prednisone
 Definition
decrease Cox2/phospholipase A2 (inhibition
Term
COLCHICINE
 Definition
microtubule depolymerization
Term
Allopurinol
 Definition
xanthine oxidase inhibition
Term
Probenacid
 Definition
promote renal clearance
Term
Gemcitabine
 Definition
antimetabolite
Term
Etoposide
 Definition
Topo-1 poison
Term
Bcr-abl inhibitor
 Definition
Imatinib
Term
Cisplatin
 Definition
DNA cross links
Term
Paclitaxel
 Definition
microtubule poison
Term
Bevacizumab
 Definition
anti-angiogenasis (VEGF inhibitor)
Term
Sorafenib
 Definition
anti-angiogenasis (VEGFR signaling inhibitor)e and Ras via RTK inhibition
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