Term
| Function of Cerebrospinal Fluid |
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Definition
| Provides a system for the exchange of nutrients and removal of metabolic wastes from the central nervous system. Provides cushion to minimize trauma |
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Term
| Formation of Cerebrospinal Fluid |
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Definition
Site of production is the choroid plexus
active transport and filtration |
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Term
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Definition
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Term
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Definition
| Routinely collected by lumbar puncture commonly performed between the third and fourth or fourth and fifth lumbar vertebrae. |
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Term
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Definition
| used for chemical/ serological testing |
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Term
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Definition
| Used for Microbiology studies |
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Term
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Definition
| Cell counts (least affected by traumatic tap) |
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Term
| What do you do with excess CSF? |
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Definition
| Excess fluid should be stored frozen to facilitate additional testing. |
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Term
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Definition
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Term
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Definition
| CSF supernatant that is pink/yellow/ orange. Causes for include the presence of red blood cell degradation products, i.e., pink (oxyhemoglobin), orange (heavy hemolysis), yellow (unconjugated bilirubin) |
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Term
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Definition
| indicative of intracranial hemorrhage but can also result from puncture of blood vessel during specimen collection. |
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Term
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Definition
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Term
| blood spread out over tubes |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Why can electronic counters not be used? |
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Definition
| because of variations in background counts falsely elevating normal or moderately elevate counts. |
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Term
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Definition
| the fluid is forced into a monolayer within a 6mm circle on the microscope slide. Albumin may be added to minimize cellular distortions. Microscope slide surfaces may be positively charged to improve cell attraction |
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Term
| Normal adult CSF usually contains |
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Definition
| lymphocytes and monocytes (70:30) |
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Term
| what cell dominates in children csf |
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Definition
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Term
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Definition
| Low WBC cells counts with increased lymphocytes |
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Term
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Definition
| macrophages containing RBC’s |
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Term
| Abnormal concentrations of protein usually result from |
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Definition
Alterations in permeability of the blood-brain-barrier
Increased production by neural cells
Increased metabolism by neural cells |
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Term
| Normal protein concentration in CSF |
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Definition
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Term
| primary component of the CSF |
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Definition
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Term
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Definition
| composed primarily of haptoglobin and ceruloplasmin. |
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Term
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Definition
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Term
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Definition
| carbohydrate-deficient transferrin fraction, may be present in CSF |
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Term
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Definition
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Term
| IgM, fibrinogen, and beta-lipoprotein |
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Definition
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Term
| The causes for increased protein include |
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Definition
Damage to the blood-brain-barrier
Production of immunoglobulins within the Central Nervous System
Decreased clearance of protein from the fluid
Degeneration of neural tissue |
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Term
| Low CSF glucose concentrations |
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Definition
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Term
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Definition
| Can be effective in assisting with difficult meningitis diagnosis and therapy monitoring. |
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Term
| Destruction of tissue due to hypoxia |
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Definition
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Term
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Definition
| produced by the brain cells from ammonia and alpha-ketoglutarate |
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Term
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Definition
| Permits the removal of toxic ammonia from the CNS. |
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Term
| What is glutamine used to assess |
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Definition
| assessing CNS ammonia levels. |
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Term
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Definition
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Term
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Definition
| diagnosing meningitis cases caused by gram negative bacteria |
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Term
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Definition
| tertiary or neurosyphilis |
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