Term
| • Mechanism of immunization |
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Definition
| Fetal RBCs enter mom’s circulation and immunize mother and stimulate production of anti-D |
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Term
| • Response of mother to subsequent pregnancies |
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Definition
| production of IgG antibodies stimulated by previous transfusion or pregnancy, naturally occurring maternal ABO antibodies cross placenta |
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Term
| • Results of RBC destruction in the fetus |
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Definition
| due to maternal IgG antibodies, ABO antibodies hemolyze incompatible fetal cells, could cause erthryoblastosis fetalis, heptosplenomegaly. hydrops fetalis or jaundice. |
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Term
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Definition
| most common cause of HDN, 1/5 pregnancies |
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Term
|
Definition
| severe anemia of fetus is rare, jaundice and hyperbilirubinemia 12-48 hours after birth are more common |
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Term
| • ABO HDN serological findings in baby |
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Definition
| microsphereocytes and increased RBC fragility, positive DAT in eluate |
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Term
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Definition
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Term
|
Definition
| depends on antigenic exposure, host factors, immunoglobulin class, antibody specificity, and influence of the ABO group |
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Term
| • Rh HDN serological findings in mother |
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Definition
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Term
| • Rh HDN serological findings in baby |
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Definition
| hemolysis, coated RBCs, Positive DAT |
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Term
| • Material ABO/Rh, antibody screen and ID and antibody titers |
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Definition
| to determine if the mother has an antibody, if so which kind of antibody, titers to determine highest dilution at which a reaction is observed |
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Term
| • Paternal Phenotype/genotype |
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Definition
| determine if the fetus has the capability to produce a D antigen |
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Term
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Definition
| determine genes present in fetus |
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Term
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Definition
| measure MCA-PSV to determine anemia, color to detect direction of blood flow |
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Term
|
Definition
| determine highest dilution at which a reaction is observed, single 4 fold increase of two consecutive 2 fold increased is clinically significant, cannot predict severity of HDFN. |
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Term
| • Exchange transfusion purpose |
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Definition
| : after birth, given is no prenatal care has been given, and no intrauterine transfusion could have been performed. Used to remove high levels of bilirubin and prevent kernicterus |
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Term
| • Indicators for use of exchange transfusion |
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Definition
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Term
| • Criteria for selection of blood for exchange transfusion |
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Definition
| whole blood, compatible RBCs |
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Term
| • Criteria for neonatal and intrauterine transfusions |
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Definition
| MCA-MSV indicates anemia, fetal hydrops noted on ultrasound, hemoglobin <10 g/dL, amniotic fluid change in OD above 450nm |
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Term
| • Purpose of Rh immune globulin |
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Definition
| prevents acute immunization induced by RBC antigens by the concurrent administration of corresponding RBC antibody. |
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Term
| • Criteria for use Rh immune globulin |
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Definition
| a vial at 28 weeks, and within 72 hours of delivery |
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